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Hepatocyte

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Hepatocytes make up 70-80% of the cytoplasmic mass of the liver. These cells are involved in protein synthesis, protein storage and transformation of carbohydrates, synthesis of cholesterol, bile salts and phospholipids, and detoxification, modification and excretion of exogenous and endogenous substances. The hepatocyte also initiates the formation and secretion of bile.

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News tagged with liver cells

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New Role for a 'Foxy Old Gene'

Researchers find a new role for a 'Foxy Old Gene'

Medicine & Health / Research

created Aug 01, 2008 | popularity 4.8 / 5 (5) | comments 0

Researchers at the University of Pennsylvania School of Medicine have discovered that a protein called FOXA2 controls genes that maintain the proper level of bile in the liver. FOXA2 may become the focus for ...


Stem cells crucial to diabetes cure in mice

Medicine & Health / Research

created Mar 16, 2009 | popularity 5 / 5 (3) | comments 1

More than five years ago, Dr. Lawrence C.B. Chan and colleagues in his Baylor College of Medicine laboratory cured mice with type 1 diabetes by using a gene to induce liver cells to make insulin.


New steps forward in cell reprogramming

New steps forward in cell reprogramming

Biology / Cell & Microbiology

created Aug 10, 2009 | popularity 5 / 5 (3) | comments 0

(PhysOrg.com) -- Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General Hospital (MGH) have substantially improved the odds of successfully reprogramming differentiated cells into induced ...


Senescence in liver cells can provoke a beneficial immune reaction

Medicine & Health / Other

created Aug 21, 2008 | popularity 5 / 5 (2) | comments 0

Although post-reproductive life in humans is often associated with decline and a loss of powers, an analogous state in certain cells -- called senescence -- is proving to be one of ironic potency. Scientists at Cold Spring ...


Model tissue system reveals cellular communication via amino acids

Medicine & Health / Research

created Apr 03, 2009 | popularity 5 / 5 (2) | comments 0

A team of researchers from the Massachusetts General Hospital Center for Engineering in Medicine (MGH-CEM) has found the first evidence of cell-to-cell communication by amino acids, the building blocks of proteins, rather ...


Old diabetes drug teaches experts new tricks

Medicine & Health / Research

created May 14, 2009 | popularity 5 / 5 (2) | comments 0

Research from the Johns Hopkins Children's Center reveals that the drug most commonly used in type 2 diabetics who don't need insulin works on a much more basic level than once thought, treating persistently elevated blood ...


Building the right cells

Biology /

created Jan 04, 2009 | popularity 5 / 5 (1) | comments 1

Just after 5 p.m. doors rattle shut and feet begin to shuffle past the narrow lab where Karim Si-Tayeb sits hunched over a microscope, all but invisible to the scientists leaving the Medical College of Wisconsin. Si-Tayeb ...


Discovery could lead to a new animal model for hepatitis C

Discovery could lead to a new animal model for hepatitis C

Medicine & Health / Research

created Jan 28, 2009 | popularity 5 / 5 (1) | comments 0

During its career, the potentially fatal hepatitis C virus has banked its success on a rather unusual strategy: its limitations. Its inability to infect animals other than humans and chimpanzees has severely ...


Suppressing cancer with a master control gene

Medicine & Health / Cancer

created Feb 23, 2009 | popularity 5 / 5 (1) | comments 0

Starting with the tiny fruit fly and then moving into mice and humans, researchers at VIB and K. U. Leuven show that expression of the same gene suppresses cancer in all three organisms. Reciprocally, switching off the gene ...


Researchers identify genes linked to chemoresistance

Medicine & Health / Cancer

created Jul 20, 2009 | popularity 5 / 5 (1) | comments 0

Two genes may contribute to chemotherapy resistance in drugs like 5-fluorouracil, which is used in liver cancer treatment, according to Virginia Commonwealth University Massey Cancer Center researchers.


New strategy for inhibiting virus replication

Medicine & Health / Research

created Aug 14, 2009 | popularity 5 / 5 (1) | comments 1

Viruses need living cells for replication and production of virus progeny. Thus far, antiviral therapy primarily targets viral factors but often induces therapy resistance. New improved therapies attempt to targets cellular ...


Transplanted Liver Cells Hold Hope for Treating Inherited Diseases

Transplanted Liver Cells Hold Hope for Treating Inherited Diseases

Medicine & Health / Research

created Oct 09, 2009 | popularity 4 / 5 (1) | comments 0

(PhysOrg.com) -- Mike Gibson, chair of the Department of Biological Sciences at Michigan Technological University, has spent most of his professional life trying to better understand genetic metabolic disorders ...


Antifibrotic effects of green tea

Medicine & Health / Health

created Nov 18, 2009 | popularity 4 / 5 (1) | comments 0

Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis. Hepatoprotective effects ...


To protect against liver disease, body puts cells 'under arrest'

Medicine & Health / Diseases

created Aug 21, 2008 | popularity not rated yet | comments 0

A stable form of cell-cycle arrest known to offer potent protection against cancer also limits liver fibrosis, a condition characterized by an excess of fibrous tissue, according to a new report in the August 22nd Cell, a Cell ...


Liver Stem Cells

Stem cells with potential to regenerate injured liver tissue identified

Medicine & Health / Research

created Nov 12, 2008 | popularity not rated yet | comments 0

A novel protein marker has been found that identifies rare adult liver stem cells, whose ability to regenerate injured liver tissue has the potential for cell-replacement therapy. For the first time, researchers ...