Hepatotoxicity
hideHepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents when taken in overdoses and sometimes even when introduced within therapeutic ranges may injure the organ. Other chemical agents such as those used in laboratories and industries, natural chemicals (e.g. microcystins) and herbal remedies can also induce hepatotoxicity. Chemicals that cause liver injury are called hepatotoxins.
More than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market. Chemicals often cause subclinical injury to liver which manifests only as abnormal liver enzyme tests. Drug induced liver injury is responsible for 5% of all hospital admissions and 50% of all acute liver failures.
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News tagged with liver damage
Rare pancreatic cancer patients may live longer when treated with radiation therapy
Nov 20, 2009 |
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Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors (PNTs), despite such tumors being commonly considered resistant to radiation therapy, according to ...
FDA launches plan to curb accidental overdoses
Medicine & Health / Medications
Nov 04, 2009 |
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(AP) -- The Food and Drug Administration is launching a program to try and prevent millions of accidental drug overdoses that occur each year due to medication errors, misuse and other problems.
Researchers pave the way for effective liver treatments
Oct 09, 2009 |
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A combination of bioengineering and medical research at the University of California, San Diego has led to a new discovery that could pave the way for more effective treatments for liver disease.
FDA questions safety of Glaxo kidney cancer drug
Medicine & Health / Medications
Oct 01, 2009 |
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(AP) -- Federal regulators said Thursday an experimental kidney cancer drug from GlaxoSmithKline may cause liver problems, potentially outweighing its ability to slow the disease.
FDA probes liver damage with weight loss pill alli
Medicine & Health / Medications
Aug 24, 2009 |
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(AP) -- The Food and Drug Administration is investigating reports of liver damage in patients taking alli, the only nonprescription weight loss drug approved by the agency.
Scientists link immune system's natural killer cells to infant liver disease
Jul 22, 2009 |
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Scientists have linked an overactive response by one of the immune system's key weapons against infection - natural killer, or NK, cells - to the onset of biliary atresia in infants, a disease where blocked ...
FDA orders overdose warnings for Darvocet
Medicine & Health / Medications
Jul 07, 2009 |
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(AP) -- The government is letting the painkillers Darvocet, Darvon and their generic cousins stay on the market but ordered stronger warnings against deadly overdoses on Tuesday.
Questions and answers about pain medicine dangers
Jul 07, 2009 |
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(AP) -- A Food and Drug Administration panel has recommended limits on Tylenol and other drugs containing acetaminophen because of risks for liver failure. Maximum recommended doses for over-the-counter Tylenol would be ...
Liver disease 'shrunk' by blood-pressure drug
Jun 01, 2009 |
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A blood-pressure medicine has been shown to reverse the effects of early-stage liver failure in some patients.
'Gene silencing' may improve treatment of a deadly complication of liver disease
May 27, 2009 |
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A technique that “silences,” or turns off, genes shows promise as a potential new treatment for liver fibrosis — the disease that leads to cirrhosis — scientists in Tennessee are reporting. Their study is scheduled for the ...
What teens don't know about OTC medications can hurt them
Medicine & Health / Medications
May 04, 2009 |
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Teens, who are starting to make more decisions about their own health care, may not know enough about over-the-counter pain medications to avoid complications or inadvertent misuse.
FDA: Dieters should stop Hydroxycut use now
Medicine & Health / Medications
May 01, 2009 |
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(AP) -- Government health officials warned dieters and body builders Friday to immediately stop using Hydroxycut, a widely sold supplement linked to cases of serious liver damage and at least one death.
Chronic drinking causes more liver injury than acute or binge drinking
Feb 03, 2009 |
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Alcohol consumption is known to cause liver damage. Yet the specifics of alcohol-induced liver injury can differ depending on the pattern of drinking. New rodent findings show that chronic drinking causes more injury - ...
Aspirin can prevent liver damage that afflicts millions
Jan 26, 2009 |
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Simple aspirin may prevent liver damage in millions of people suffering from side effects of common drugs, alcohol abuse, and obesity-related liver disease, a new Yale University study suggests.
New treatment option for latent tuberculosis
Jan 22, 2009 |
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Patients who are infected with the latent form of tuberculosis (TB) show no symptoms and are not contagious, yet they pose the biggest challenge when it comes to controlling the disease. The latest study by Dr. Dick Menzies ...
