News tagged with lysosomes
Inventive approach may improve enzyme replacement therapy for Fabry disease
Oct 22, 2009 |
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A new study uses a creative structure-based remodeling strategy to design a therapeutic protein that exhibits significant advantages over currently available treatments for a rare disease that often leads to cardiac and renal ...
Immune reaction to metal debris leads to early failure of joint implants
Mar 04, 2009 |
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Researchers at Rush University Medical Center have identified a key immunological defense reaction to the metals in joint replacement devices, leading to loosening of the components and early failure.
Search results for lysosomes
Researchers identify missing target for calcium signaling
Medicine & Health / Neuroscience
Apr 22, 2009 |
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An international study led by Ohio State University neuroscience researchers describes one of the missing triggers that controls calcium inside cells, a process important for muscle contraction, nerve-cell transmission, insulin ...
Calcium aids protein folding as therapy for enzymes in types of lysosomal storage diseases
Biology /
Feb 05, 2008 |
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Lysosomes are organelles that break down macromolecules in a cell, and this process is crucial for maintaining healthy cells. A lysosomal storage disease results from deficient activity of the hydrolytic enzymes, responsible ...
2002 oil spill caused changes in the cell structure of mussels
Mar 25, 2009 |
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The oil spill from the Prestige petroleum oil tanker in 2002 caused serious damage to the ecosystems in the Bay of Biscay. A PhD thesis at the University of the Basque Country (UPV/EHU) has studied the consequences of this ...
Toxicity mechanism identified for Parkinson's disease
Jan 02, 2009 |
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Neurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson's disease and other neurodegenerative diseases.
Nanoprobes hit targets in tumors, could lessen chemo side effects
Nanotechnology / Bio & Medicine
Dec 14, 2009 |
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(PhysOrg.com) -- Tiny nanoprobes have shown to be effective in delivering cancer drugs more directly to tumor cells - mitigating the damage to nearby healthy cells - and Purdue University research has shown that the nanoprobes ...
Study outlines how stroke, head injury can increase risk of Alzheimer's disease
Jun 06, 2007 |
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Researchers from the MassGeneral Institute for Neurodegenerative Disorders (MGH-MIND) have discovered how the death of brain cells caused by a stroke or head injury may cause generation of amyloid-beta protein – the key component ...
Researchers discover new fat-fighting pathway
Apr 01, 2009 |
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Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a process that controls the amount of fat that cells store for use as a back-up energy source. Disruption of this process ...
Scientists successfully reprogram blood cells
Nov 09, 2009 |
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Researchers have transplanted genetically modified hematopoietic stem cells into mice so that their developing red blood cells produce a critical lysosomal enzyme -preventing or reducing organ and central nervous system damage ...
With just 3 affected individuals, researchers find gene behind rare form of epilepsy
Feb 28, 2008 |
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Researchers have found a gene responsible for a particularly debilitating form of epilepsy that also leads to kidney failure, according to a report published online on February 28th and also in the March 7th print issue of ...
Research reveals lipids' unexpected role in triggering death of brain cells
Nov 12, 2009 |
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The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St. Jude Children's Research Hospital ...
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