News tagged with mdm2
Three is the magic number: A chain reaction required to prevent tumor formation
Protein p53 is known for controlling the life and death of a cell and has a key role in cancer research. P53 is known to be inactive in 50 percent of cancer patients. If researchers succeed in re-establishing the presence ...
Jan 20, 2012 |
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New understanding of how to prevent destruction of a tumor suppressor
Researchers from the Indiana University School of Medicine and colleagues at the University of Texas Southwestern and Case Western University have determined how the protein Mdm2, which is elevated in late-stage ...
Dec 07, 2009 |
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The 2 faces of Mdmx: Why some tumors don't respond to radiation and chemotherapy
A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells. In their latest study, ...
Jul 06, 2009 |
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Search results for mdm2
Molecule Nutlin-3a activates a signal inducing cell death and senescence in primary brain tumors
Researchers of Apoptosis and Cancer Group of the Bellvitge Biomedical Research Institute (IDIBELL) have found that a small molecule, Nutlin-3a, an antagonist of MDM2 protein, stimulates the signalling pathway of another protein, ...
Apr 20, 2011 |
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New drug shrinks cancer in animals, study shows
A study led by researchers at the University of Michigan Comprehensive Cancer Center showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.
Apr 06, 2011 |
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Researchers discover potential cancer therapy target
One of the most important genes in the human genome is called p53 and its function is to suppress tumours, according to Roger Leng, a researcher in the Faculty of Medicine & Dentistry. Leng has discovered the mechanism by ...
Feb 14, 2011 |
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Small molecule may disarm enemy of cancer-fighting p53
A pioneering clinical trial is testing the effectiveness in leukemia of a small molecule that shuts down MDM2, a protein that can disable the well-known tumor suppressor p53.
Dec 07, 2010 |
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Study identifies key molecules in multiple myeloma
New research links three molecules to a critical tumor suppressor gene that is often turned off in multiple myeloma, a presently incurable cancer of the blood.
Oct 26, 2010 |
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Study sheds light on cancer-causing gene regulation
Researchers at Beth Israel Deaconess Medical Center (BIDMC) have uncovered the genes that regulate MDM2, an oncogene that, in turn, regulates the tumor suppressor protein p53. But instead of an on-off switch for MDM2, the ...
Aug 16, 2010 |
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Advances reported in quest for drugs targeting childhood cancer
Investigators believe they have identified the founding member of a chemical family they hope will lead to a new class of cancer drugs, the first designed specifically against a childhood tumor, according ...
Mar 29, 2010 |
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Human Mdm2: A new molecular link to late-stage metastatic breast cancer
A large proportion of late-stage breast cancers that have spread to other parts of the body (metastatic breast cancers) are characterized by overexpression of the protein Mdm2.
Dec 02, 2009 |
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Antitumor activity of nutlin-3 in neuroblastoma with wild-type p53
The small-molecule inhibitor nutlin-3 may be a viable treatment option for neuroblastoma patients with wild-type p53 activity, according to a new study published online November 10 in the Journal of the National Cancer In ...
Nov 10, 2009 |
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New research on the 'guardian of the genome'
(PhysOrg.com) -- Protein p53 protects the body against cancer and is knocked out in many cancer tumours. Researchers at Karolinska Institutet have identified two molecules that can restore p53's cancer-killing properties. ...
May 12, 2009 |
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List of search results for mdm2
