Related topics: drug

A rat's brain, on and off methamphetamine

Drug addiction is a vicious cycle of reward and withdrawal. Chronic users often relapse because of the unpleasant physical and psychological symptoms they experience when they stop taking the drug. Now, researchers report ...

Nanomechanical detection of methamphetamines and designer drugs

(Phys.org) —The widespread use of methamphetamines and related designer drugs is a major challenge for our society, with significant impact on health and social security. In the journal Angewandte Chemie, Italian researchers ...

Drug residues in Swedish sewage water

Chemists at Umeå University in Sweden have been able to trace narcotics substances and prescription drugs in measurements of wastewater from 33 Swedish sewage treatment plants. Cocaine, amphetamine, and methamphetamine, ...

Anthrax-killing foam proves effective in meth lab cleanup

Sandia's decontamination foam, developed more than a decade ago and used to decontaminate federal office buildings and mailrooms during the 2001 anthrax attacks, is now being used to decontaminate illegal methamphetamine ...

Toward a vaccine for methamphetamine abuse

Scientists are reporting development of three promising formulations that could be used in a vaccine to treat methamphetamine addiction — one of the most serious drug abuse problems in the U.S. The report appears in ...

New research shows massive ad campaign didn't reduce meth use

(PhysOrg.com) -- In 2005, Montana had one of the highest rates of methamphetamine use in the United States. Private funds were used to launch a public awareness campaign, and public dollars followed. Seven other states launched ...

Snails on methamphetamine

Crystal meth (methamphetamine) is a highly addictive drug that seduces victims by increasing self-esteem and sexual pleasure, and inducing euphoria. But once hooked, addicts find the habit hard to break. Barbara Sorg from ...

page 1 from 2

Methamphetamine

Methamphetamine (/mɛθæm'fɛtəmiːn/ also known as metamfetamine (INN), methylamphetamine, N-methylamphetamine, and desoxyephedrine) is a psychostimulant and sympathomimetic drug.

A member of the family of phenylethylamines, methamphetamine is chiral, with two isomers:

The levorotary form, called levomethamphetamine, is an over-the-counter drug used in inhalers for nasal decongestion. Levomethamphetamine does not possess any significant central nervous system activity or addictive properties. The remainder of this article deals only with the dextrorotatory form, called dextromethamphetamine, and the racemic form.

Methamphetamine enters the brain and triggers a cascading release of dopamine, serotonin and norepinephrine. It is highly active in the mesolimbic reward pathways of the brain, inducing intense euphoria, with risk for addiction. To a lesser extent, methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor with high concentrations serving as a monoamine oxidase inhibitor. Users may become hypersexual or obsessed with a task, thought or activity. Withdrawal is characterized by excessive sleeping, eating, and major depression, often accompanied by anxiety and drug-craving. Methamphetamine users may take sedatives such as benzodiazepines as a means of easing their "come down", anxiety or enable them to sleep.

Methamphetamine has medical uses as well as the potential to cause addiction. Methamphetamine addiction typically occurs when a person begins to use the drug as a stimulant, for its powerful enhancing effects on sex, mood and energy, alertness and ability to concentrate, and weight loss and appetite suppression, among its other psychological and physical effects.[citation needed] Over time tolerance develops, and users have greater difficulty functioning and experiencing pleasure than they did before, which persists indefinitely due to neurotoxicity produced by methamphetamine in long-term recovered addicts.[citation needed]

Nicknames for methamphetamine are numerous and vary significantly from region to region, some common nicknames for methamphetamine include "crank", "meth", "ice", "crystal", "glass", "shabu" or "syabu" (Philippines), "tik" (South Africa), "P" (New Zealand), "piko" (Slovakia), and "yaa baa" (Thailand). Methamphetamine is sometimes referred to as "speed", but this term is generally reserved for regular amphetamine and dextroamphetamine.

This text uses material from Wikipedia, licensed under CC BY-SA