News tagged with mice lacking
Growth of new brain cells requires 'epigenetic' switch
Jan 08, 2009 |
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New cells are born every day in the brain's hippocampus, but what controls this birth has remained a mystery. Reporting in the January 1 issue of Science, neuroscientists at the Johns Hopkins University School of Medicine have d ...
Scientists identify 'border patrol agents' in the gut
Biology /
Dec 08, 2008 |
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Researchers at UT Southwestern Medical Center have shown in mice how and under what circumstances the gut activates its defensive mechanisms to prevent illness.
Molecules help the immune system to detect cells infected with West Nile virus
Feb 05, 2009 |
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New research reveals a model of host-pathogen interaction that explains how the immune system finds and destroys cells infected with a potentially lethal brain virus. The study, published online on February 5th in Immunity, a Cell ...
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Bone-cell control of energy generation is regulated by the protein Atf4
Aug 10, 2009 |
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Bone cells known as osteoblasts were recently shown to have a role in controlling the biochemical reactions that generate energy via secretion of the molecule osteocalcin. Gerard Karsenty and colleagues, at Columbia University ...
Researchers discover new link to schizophrenia
May 08, 2008 |
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Neuroscientists at Johns Hopkins have discovered that mice lacking an enzyme that contributes to Alzheimer disease exhibit a number of schizophrenia-like behaviors. The finding raises the possibility that this enzyme may ...
Afib triggered by a cell that resembles a pigment-producing skin cell
Oct 12, 2009 |
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The source and mechanisms underlying the abnormal heart beats that initiate atrial fibrillation (Afib), the most common type of abnormal heart beat, have not been well determined. However, a group of researchers at the University ...
Iron regulates the TLR4 inflammatory signaling pathway
Oct 05, 2009 |
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Iron is a micronutrient essential to the survival of both humans and disease-causing microbes. Changes in iron levels therefore affect the severity of infectious diseases. For example, individuals with mutations in their ...
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
Feb 24, 2009 |
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Scientists have determined that a specific gene plays a role in the weight-gain response to a high-fat diet. The finding in an animal study suggests that blocking this gene could one day be a therapeutic strategy to reduce ...
Heart saves muscle
May 25, 2009 |
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A heart muscle protein can replace its missing skeletal muscle counterpart to give mice with myopathy a long and active life, show Nowak et al. The findings will be published online on Monday, May 25, 2009 ...
Leptin's long-distance call to the pancreas
Biology /
Dec 22, 2008 |
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Rube Goldberg—the cartoonist who devised complex machines for simple tasks—would have smiled at one of leptin's mechanisms for curbing insulin release. As Hinoi et al. show, the fat-derived hormone enlists ...
Too hot to handle! Scientists identify heat sensing regulator
May 13, 2008 |
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Neuroscientists at Johns Hopkins are a step closer to understanding pain sensitivity - specifically why it’s variable instead of constant - having identified a gene that regulates a heat-activated molecular sensor. Their ...
Bad mitochondria may actually be good for you
Jul 22, 2009 |
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Mice with a defective mitochondrial protein called MCLK1 produce elevated amounts of reactive oxygen when young; that should spell disaster, yet according to a study in this week's JBC these mice actually age at a slower ...
Novel mechanisms controlling insulin release and fat deposition discovered
May 13, 2008 |
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Scientists at the Swedish medical university Karolinska Institutet have in two recent studies shown that a receptor called ALK7 plays important roles in the regulation of body fat deposition as well as the release of insulin ...
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