Mitochondrion
hideIn cell biology, a mitochondrion (plural mitochondria) is a membrane-enclosed organelle found in most eukaryotic cells. These organelles range from 0.5–10 micrometers (μm) in diameter. Mitochondria are sometimes described as "cellular power plants" because they generate most of the cell's supply of adenosine triphosphate (ATP), used as a source of chemical energy. In addition to supplying cellular energy, mitochondria are involved in a range of other processes, such as signaling, cellular differentiation, cell death, as well as the control of the cell cycle and cell growth. Mitochondria have been implicated in several human diseases, including mitochondrial disorders and cardiac dysfunction, and may play a role in the aging process. The word mitochondrion comes from the Greek μίτος or mitos, thread + χονδρίον or khondrion, granule.
Several characteristics make mitochondria unique. The number of mitochondria in a cell varies widely by organism and tissue type. Many cells have only a single mitochondrion, whereas others can contain several thousand mitochondria. The organelle is composed of compartments that carry out specialized functions. These compartments or regions include the outer membrane, the intermembrane space, the inner membrane, and the cristae and matrix. Mitochondrial proteins vary depending on the tissue and the species. In humans, 615 distinct types of proteins have been identified from cardiac mitochondria; whereas in Murinae (rats), 940 proteins encoded by distinct genes have been reported. The mitochondrial proteome is thought to be dynamically regulated. Although most of a cell's DNA is contained in the cell nucleus, the mitochondrion has its own independent genome. Further, its DNA shows substantial similarity to bacterial genomes.
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News tagged with mitochondria
To keep muscles strong, the 'garbage' has to go
Dec 01, 2009 |
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In order to maintain muscle strength with age, cells must rid themselves of the garbage that accumulates in them over time, just as it does in any household, according to a new study in the December issue of Cell Metabolism. In the ...
Powerhouses in the cell dismantled
Oct 15, 2009 |
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All of life is founded on the interactions of millions of proteins. These are the building blocks for cells and form the molecular mechanisms of life. The problem is that proteins are extremely difficult to study, particularly ...
Too much of a good thing? Scientists explain cellular effects of vitamin A overdose and deficiency
Oct 08, 2009 |
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If a little vitamin A is good, more must be better, right? Wrong! New research published online in the FASEB Journal shows that vitamin A plays a crucial role in energy production within cells, explaining why too much or too ...
MicroRNA drives cells' adaptation to low-oxygen living
Oct 06, 2009 |
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Researchers have fresh insight into an evolutionarily ancient way that cells cope when oxygen levels decline, according to a new study in the October 7th issue of Cell Metabolism. In studies of cells taken from the lining ...
'Anti-Atkins' low protein diet extends lifespan in flies
Oct 01, 2009 |
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Flies fed an "anti-Atkins" low protein diet live longer because their mitochondria function better. The research, done at the Buck Institute for Age Research, shows that the molecular mechanisms responsible for the lifespan ...
How mitochondrial gene defects impair respiration, other major life functions
Sep 24, 2009 |
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Researchers are delving into abnormal gene function in mitochondria, structures within cells that power our lives. Mitochondria are the place where energy is generated from the most basic molecules of food. Because this function ...
New technique could eliminate inherited mitochondrial disease
Aug 26, 2009 |
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Researchers funded by the National Institutes of Health have developed an experimental technique with the potential to prevent a class of hereditary disorders passed on from mother to child. The technique, as yet conducted ...
Unstable proteins can cause premature ageing
Aug 06, 2009 |
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(PhysOrg.com) -- The normal ageing process has long been linked to problems with cell respiration, the process through which the cells extract energy from nutrients. Researchers at the Swedish medical university Karolinska ...
Bad mitochondria may actually be good for you
Jul 22, 2009 |
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Mice with a defective mitochondrial protein called MCLK1 produce elevated amounts of reactive oxygen when young; that should spell disaster, yet according to a study in this week's JBC these mice actually age at a slower ...
Estrogen can reduce stroke damage by inactivating protein
Jul 16, 2009 |
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Estrogen can halt stroke damage by inactivating a tumor-suppressing protein known to prevent many cancers, Medical College of Georgia researchers say.
Controlling the fate of cells
Jul 13, 2009 |
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A protein found in cells has been shown to play a pivotal role in determining whether a cell lives or dies.
Scientists reveal connection between cancer and human evolution
Jul 02, 2009 |
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Researchers at Ben-Gurion University of the Negev (BGU) have discovered that gene mutations that once helped humans survive may increase the possibility for diseases, including cancer.
Super-sleepers could help super-sizers!
Jun 29, 2009 |
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Burrowing frogs can survive buried for several years without food or water. Scientists have discovered that the metabolism of their cells changes radically during the dormancy period allowing the frogs to ...
Protein regulates movement of mitochondria in brain cells
Jun 15, 2009 |
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Scientists have identified a protein in the brain that plays a key role in the function of mitochondria - the part of the cell that supplies energy, supports cellular activity, and potentially wards off threats from disease. ...
Scientists investigate estrogen, heart disease connection in women
May 04, 2009 |
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A new study on old rats by a Penn State researcher will shed light on the connection between estrogen deficiency, heart disease and aging in women.
