Mitochondrion
hideIn cell biology, a mitochondrion (plural mitochondria) is a membrane-enclosed organelle found in most eukaryotic cells. These organelles range from 0.5–10 micrometers (μm) in diameter. Mitochondria are sometimes described as "cellular power plants" because they generate most of the cell's supply of adenosine triphosphate (ATP), used as a source of chemical energy. In addition to supplying cellular energy, mitochondria are involved in a range of other processes, such as signaling, cellular differentiation, cell death, as well as the control of the cell cycle and cell growth. Mitochondria have been implicated in several human diseases, including mitochondrial disorders and cardiac dysfunction, and may play a role in the aging process. The word mitochondrion comes from the Greek μίτος or mitos, thread + χονδρίον or khondrion, granule.
Several characteristics make mitochondria unique. The number of mitochondria in a cell varies widely by organism and tissue type. Many cells have only a single mitochondrion, whereas others can contain several thousand mitochondria. The organelle is composed of compartments that carry out specialized functions. These compartments or regions include the outer membrane, the intermembrane space, the inner membrane, and the cristae and matrix. Mitochondrial proteins vary depending on the tissue and the species. In humans, 615 distinct types of proteins have been identified from cardiac mitochondria; whereas in Murinae (rats), 940 proteins encoded by distinct genes have been reported. The mitochondrial proteome is thought to be dynamically regulated. Although most of a cell's DNA is contained in the cell nucleus, the mitochondrion has its own independent genome. Further, its DNA shows substantial similarity to bacterial genomes.
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News tagged with mitochondria
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Chemical concoctions can smooth over wrinkles and hide those pesky grays, but what about the signs of aging that aren't so easy to fix, such as losing muscle mass? Cutting calories early could help, say University of Florida ...
Scientists reveal connection between cancer and human evolution
Jul 02, 2009 |
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Researchers at Ben-Gurion University of the Negev (BGU) have discovered that gene mutations that once helped humans survive may increase the possibility for diseases, including cancer.
Cannabis compound can help cells
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(PhysOrg.com) -- Cannabis has been used recreationally and for medicinal purposes for centuries, yet its 60 plus active components are only partly understood. Now scientists have discovered how a compound ...
Analysis knocks down theory on origin of cell structure
Apr 22, 2009 |
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(PhysOrg.com) -- Understanding how living cells originated and evolved into their present forms remains a fundamental research area in biology, one boosted in recent years by the introduction of new tools ...
New platinum compound shows promise in tumor cells
Dec 07, 2009 |
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(PhysOrg.com) -- MIT chemists have developed a new platinum compound that is as powerful as the commonly used anticancer drug cisplatin but better able to destroy tumor cells.
What's Feeding Cancer Cells?
Feb 16, 2009 |
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Cancer cells need a lot of nutrients to multiply and survive. While much is understood about how cancer cells use blood sugar to make energy, not much is known about how they get other nutrients. Now, researchers at the Johns ...
New research helps explain genetics of Parkinson's disease
Nov 24, 2008 |
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A new study by Narendra et al. suggests that Parkin, the product of the Parkinson's disease-related gene Park2, prompts neuronal survival by clearing the cell of its damaged mitochondria.
Too much of a good thing? Scientists explain cellular effects of vitamin A overdose and deficiency
Oct 08, 2009 |
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If a little vitamin A is good, more must be better, right? Wrong! New research published online in the FASEB Journal shows that vitamin A plays a crucial role in energy production within cells, explaining why too much or too ...
To keep muscles strong, the 'garbage' has to go
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In order to maintain muscle strength with age, cells must rid themselves of the garbage that accumulates in them over time, just as it does in any household, according to a new study in the December issue of Cell Metabolism. In the ...
Key protein in cellular respiration discovered
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Many diseases derive from problems with cellular respiration, the process through which cells extract energy from nutrients. Researchers at the Swedish medical university Karolinska Institutet have now discovered a new function ...
Super-sleepers could help super-sizers!
Jun 29, 2009 |
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Burrowing frogs can survive buried for several years without food or water. Scientists have discovered that the metabolism of their cells changes radically during the dormancy period allowing the frogs to ...
Bad mitochondria may actually be good for you
Jul 22, 2009 |
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Mice with a defective mitochondrial protein called MCLK1 produce elevated amounts of reactive oxygen when young; that should spell disaster, yet according to a study in this week's JBC these mice actually age at a slower ...
How mitochondrial gene defects impair respiration, other major life functions
Sep 24, 2009 |
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Researchers are delving into abnormal gene function in mitochondria, structures within cells that power our lives. Mitochondria are the place where energy is generated from the most basic molecules of food. Because this function ...
MicroRNA drives cells' adaptation to low-oxygen living
Oct 06, 2009 |
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Researchers have fresh insight into an evolutionarily ancient way that cells cope when oxygen levels decline, according to a new study in the October 7th issue of Cell Metabolism. In studies of cells taken from the lining ...
Unstable proteins can cause premature ageing
Aug 06, 2009 |
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(PhysOrg.com) -- The normal ageing process has long been linked to problems with cell respiration, the process through which the cells extract energy from nutrients. Researchers at the Swedish medical university Karolinska ...
