Monoclonal antibodies
hideMonoclonal antibodies (mAb or moAb) are monospecific antibodies that are identical because they are produced by one type of immune cell that are all clones of a single parent cell. Given almost any substance, it is possible to create monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the generic drug name ends in -mab (see "Nomenclature of monoclonal antibodies").
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News tagged with monoclonal antibodies
New cancer target for non-Hodgkin's lymphoma
Nov 22, 2009 |
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Physician-scientists from Weill Cornell Medical College have discovered a molecular mechanism that may prove to be a powerful target for the treatment of non-Hodgkin's lymphoma, a type of cancer that affects lymphocytes, ...
Early-stage, HER2-positive breast cancer patients at increased risk of recurrence
Nov 02, 2009 |
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Early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared to those with early-stage disease who do not express the aggressive protein, ...
Breakthrough in fight against Hendra virus
Oct 30, 2009 |
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(PhysOrg.com) -- There has been a breakthrough in the fight against the deadly Hendra virus following the development of a treatment which shows great potential to save the lives of people who become infected ...
Researchers induce HIV-neutralizing antibodies that recognize HIV-1 envelope protein, lipids
Medicine & Health / HIV & AIDS
Sep 01, 2009 |
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For the first time, researchers have experimentally induced antibodies that neutralize HIV-1 and simultaneously recognize both HIV-1 envelope protein and lipids. The results were reported by U.S. Military HIV Research Program ...
Scientists develop a new HIV microbicide -- and a way to mass produce it in plants
Medicine & Health / HIV & AIDS
May 28, 2009 |
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In what could be a major pharmaceutical breakthrough, research published online in The FASEB Journal describes how scientists from St George's, University of London have devised a one-two punch to stop HIV. First the report ...
New therapy enlists immune system to boost cure rate in a childhood cancer
May 27, 2009 |
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A multicenter research team has announced encouraging results for an experimental therapy using elements of the body's immune system to improve cure rates for children with neuroblastoma, a challenging cancer of the nervous ...
Two targeted therapies likely better than one in patients with aggressive lymphoma
May 15, 2009 |
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When combined with a cocktail of chemotherapy drugs, two monoclonal antibodies, instead of one, appear to offer superior results in patients with diffuse large B-cell lymphoma, according to Mayo Clinic researchers working ...
A new test for a deadly fungal infection in patients with damaged immune systems
Apr 02, 2009 |
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A quicker, cheaper and more accurate test for deadly Aspergillus fumigatus fungal infections in patients with damaged or suppressed immune systems was described today, (Thursday 2 April) at the Society for General Microb ...
A new molecular marker of gastric cancer
Mar 30, 2009 |
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Gastric cancer (GC) is one of the most common malignancies in the world with a high incidence and death rate. TNM staging system is used worldwide to predict prognosis and direct therapeutic decisions of patients with GC. ...
Monoclonal antibodies primed to become potent immune weapons against cancer
Mar 20, 2009 |
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New research suggests that monoclonal antibody therapy of cancer can be improved to be much more powerful than it is today, says a researcher at Georgetown University Medical Center's Lombardi Comprehensive Cancer Center ...
Scientists engineer new type of vaccination that provides instant immunity
Mar 02, 2009 |
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The experiments, thus far performed only in mice, appear to overcome a major drawback of vaccinations - the lag time of days, or even weeks, that it normally takes for immunity to build against a pathogen. This new method ...
Tailor-made recombinant proteins in mammals
Biology /
Feb 09, 2009 |
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A new way to direct chemical modifications to specific sites on recombinant proteins - including the monoclonal antibodies so important in the pharmaceutical industry - has been developed by Carolyn Bertozzi ...
