News tagged with mouse genome
Drugs targeting chromosomal instability may fight a particular breast cancer subtype
Another layer in breast cancer genetics has been peeled back. A team of researchers at Jefferson's Kimmel Cancer Center (KCC) led by Richard G. Pestell, M.D., PhD., FACP, Director of the KCC and Chair of the Department of ...
Feb 06, 2012 |
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Cancer drugs shown to cause mutations in mice offspring
(Medical Xpress) -- For many years, most of the studies done to see what effects cancer treatment has on the offspring of survivors, has involved radiation. This is because radiation is known to cause mutations in cells. ...
Jan 31, 2012 |
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Gene switch for odorant receptors
The olfactory sensory neurons in the nasal mucosa perceive the myriad smells in the air with the aid of odorant receptors. Each sensory neuron chooses one and only one receptor gene for expression. The probability ...
Nov 11, 2011 |
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New evidence for genetic basis of autism found
Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered that one of the most common genetic alterations in autism -- deletion of a 27-gene cluster on chromosome 16 -- causes autism-like features. ...
Oct 03, 2011 |
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Researchers develop complete map of mouse genetic variation
For decades, laboratory mice have been widely used in research aimed at understanding which genes are involved in various illnesses. But actual variations in past gene sequences of mice were unknown. While researchers were ...
Sep 26, 2011 |
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Mouse genetic blueprint developed
Researchers have developed a valuable mouse genetic blueprint that will accelerate future research and understanding of human genetics. The international team, led by researchers at the Wellcome Trust Sanger ...
Sep 14, 2011 |
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Researchers produce detailed map of gene activity in mouse brain
A new atlas of gene expression in the mouse brain provides insight into how genes work in the outer part of the brain called the cerebral cortex. In humans, the cerebral cortex is the largest part of the brain, ...
Medicine & Health / Neuroscience
Aug 24, 2011 |
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Model of a migraine indicates increased neuronal excitability as a possible cause
Familial hemiplegic migraine is a rare and severe subtype of migraine with aura, an unusual sensory experience preceding the migraine attack. Researchers from the San Raffaele Scientific Institute in Milan, and CNR Institute ...
Jun 23, 2011 |
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A knockout resource for mouse genetics
An international consortium of researchers report today in Nature that they have knocked out almost 40 per cent of the genes in the mouse genome. The completed resource will power studies of gene activity in models of hum ...
Jun 15, 2011 |
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New study solves mouse genome dilemma
Laboratory research has always been limited in terms of what conclusions scientists can safely extrapolate from animal experiments to the human population as a whole. Many promising findings in mice have not held up under ...
May 29, 2011 |
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Mouse cancer genome unveils genetic errors in human cancers
Scientists who pioneered sequencing the genomes of cancer patients to find novel genetic changes at the root of the disease now have turned their attention to a laboratory workhorse -- a mouse.
Mar 23, 2011 |
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Cholera strain evolves new mechanism for causing disease
New clinical strains of cholera appear to have evolved a distinctly different mechanism to cause the same disease according to research published in the current issue of the online journal mBio.
Dec 09, 2010 |
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Discovery leads to rapid mouse 'personalized trials' in breast cancer
One person's breast cancer is not the same as another person's, because the gene mutations differ in each tumor. That makes it difficult to match the best therapy with the individual patient.
Sep 04, 2009 |
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New reagents for genomic engineering of mouse models to understand human disease
A new study published in Disease Models and Mechanisms, reports new tools for generating specifically targeted genetic mutations in bacteria, mammalian cells and mice. The new recombinase, Dre, is similar to its predecessor, Cre, b ...
Aug 19, 2009 |
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Study pinpoints novel cancer gene and biomarker
(PhysOrg.com) -- Dana-Farber Cancer Institute scientists' discovery of a cancer-causing gene - the first in its family to be linked to cancer - demonstrates how the panoramic view of genomics and the close-up ...
Jun 24, 2009 |
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