News tagged with mutant cells
Scientists discover soy component may be key to fighting colon cancer
Nov 24, 2009 |
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A study conducted by Children's Hospital & Research Center Oakland scientists identifies a new class of therapeutic agents found naturally in soy that can prevent and possibly treat colon cancer, the third most deadly form ...
Testicular tumors may explain why some diseases are more common in children of older fathers
Oct 25, 2009 |
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A rare form of testicular tumour has provided scientists with new insights into how genetic changes (mutations) arise in our children. The research, funded by the Wellcome Trust and the Danish Cancer Society, could explain ...
Researchers identify gene that helps plant cells keep communication channels open
Biology /
Feb 17, 2009 |
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Plant cells communicate via microscopic channels called plasmodesmata that are embedded in their cell walls. For the stem cells in the plants' growing tips, called "meristems," the plasmodesmata are lifelines, allowing nutrients ...
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Chemopreventive isothiocyanates selectively depletes mutant p53 in tumor cells
Apr 20, 2009 |
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Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have demonstrated that naturally-occurring compounds can selectively deplete mutant p53 and restore "wild type" function to p53 in ...
Lamin B locks up Oct-1
Biology /
Jan 12, 2009 |
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A large fraction of the transcription factor Oct-1 is associated with the inner nuclear envelope, but how and why it is retained there was unknown.
2 drugs are better than 1 at targeting tumors with B-RAF mutations
Oct 24, 2008 |
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In a proportion of human solid tumors, in particular melanomas (a form of skin cancer that is often resistant to chemotherapy), inappropriate activation of the MEK/ERK signaling pathway as a result of mutations in the B-RAF ...
Stem cells stand up for themselves
Biology /
Aug 25, 2008 |
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Adult stem cells are not pampered pushovers. O'Reilly et al. report that certain stem cells take charge of their surroundings, molding their environment to control their division and differentiation.
Mutant gene's true effect revealed - giving new therapy hope
Oct 19, 2009 |
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(PhysOrg.com) -- Scientists have revealed how a mutant gene that causes a connective tissue disease resulting in dwarfism does so by significantly affecting the inside of cells - opening up new therapy strategies that involve ...
'Scrawny' gene keeps stem cells healthy
Biology /
Jan 07, 2009 |
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(PhysOrg.com) -- Stem cells are the body's primal cells, retaining the youthful ability to develop into more specialized types of cells over many cycles of cell division. How do they do it? Scientists at the ...
Modification of mutant huntingtin protein increases its clearance from brain cells
Apr 02, 2009 |
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A new study has identified a potential strategy for removing the abnormal protein that causes Huntington's disease (HD) from brain cells, which could slow the progression of the devastating neurological disorder. In the ...
New hope for treatment of neurodegenerative disorder
Apr 20, 2009 |
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Researchers from the University of Southern California have taken an important first step toward protecting against Huntington disease using gene therapy.
Mystery solved: Tiny protein-activator responsible for brain cell damage in Huntington disease
Jun 04, 2009 |
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Johns Hopkins brain scientists have figured out why a faulty protein accumulates in cells everywhere in the bodies of people with Huntington's disease (HD), but only kills cells in the part of the brain that controls movement, ...
New function for the protein Bcl-xL: It prevents bone breakdown
Sep 14, 2009 |
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In blood cells, the protein Bcl-xL has a well-characterized role in preventing cell death by a process known as apoptosis. However, its function(s) in osteoclasts, cells that slowly breakdown bone (a process known as resorption), ...
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