News tagged with mutant mice
Bone marrow-derived cells differentiate in the brain through mechanisms of plasticity
Bone marrow-derived stem cells (BMDCs) have been recognized as a source for transplantation because they can contribute to different cell populations in a variety of organs under both normal and pathological conditions. Many ...
Dec 19, 2011 |
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Gene found in humans, mice protects cornea transparency
A transparent cornea is essential for vision, which is why the eye has evolved to nourish the cornea without blood vessels. But for millions of people around the world, diseases of the eye or trauma spur the growth of blood ...
Dec 12, 2011 |
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Characterizing a toxic offender
The brains of individuals with Alzheimer's disease contain protein aggregates called plaques and tangles, which interfere with normal communication between nerve cells and cause progressive learning and memory ...
Medicine & Health / Neuroscience
Dec 09, 2011 |
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Is obesity a ciliopathy, triggered by malfunctioning primary cilia?
Is obesity a ciliopathy, a disorder such as polycystic kidney disease (PKD), which is triggered by a defect in the microscopic hair-like cilia that protrude from virtually every cell of humans and other vertebrates?
Dec 06, 2011 |
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Aging human bodies and aging human oocytes run on different clocks
Reproductive and somatic aging use different molecular mechanisms that show little overlap between the types of genes required to keep oocytes healthy and the genes that generally extend life span, according to Coleen Murphy, ...
Dec 06, 2011 |
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Cleft lip corrected genetically in mouse model
Scientists at Weill Cornell Medical College used genetic methods to successfully repair cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate. The research breakthrough may show the way ...
Nov 28, 2011 |
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Researchers rebuild the brain's circuitry
Neuron transplants have repaired brain circuitry and substantially normalized function in mice with a brain disorder, an advance indicating that key areas of the mammalian brain are more reparable than was ...
Medicine & Health / Neuroscience
Nov 24, 2011 |
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Brain circuits connected with memory discovered
(Medical Xpress) -- A new study published last week in Science reveals the discovery of a brain pathway that helps us link events that happen close together and play a role in memories.
Medicine & Health / Neuroscience
Nov 07, 2011 |
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Circadian clock may impact organ transplant success
Health care providers assess blood and tissue type as well as organ size and health to enhance transplant success. New research indicates that checklist might also need to include the circadian clock.
Oct 04, 2011 |
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An 'unconventional' path to correcting cystic fibrosis
Researchers have identified an unconventional path that may correct the defect underlying cystic fibrosis, according to a report in the September 2nd issue of the journal Cell. This new treatment dramatically extends the li ...
Sep 01, 2011 |
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The genome guardian's dimmer switch: Regulating p53 is a matter of life or death
Scientists at the Salk Institute for Biological Studies have found clues to the functioning of an important damage response protein in cells. The protein, p53, can cause cells to stop dividing or even to commit suicide when ...
Jun 30, 2011 |
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Animal results may pave way to treating rare mitochondrial diseases in children
A human drug that both prevents and cures kidney failure in mice sheds light on disabling human mitochondrial disorders, and may represent a potential treatment in people with such illnesses.
May 19, 2011 |
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Researchers build a better mouse model to study depression
Researchers at the University of Pittsburgh School of Medicine have developed a mouse model of major depressive disorder (MDD) that is based on a rare genetic mutation that appears to cause MDD in the majority of people who ...
May 19, 2011 |
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Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
Numerous studies show that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer. However, animal studies testing the NSAID naproxen or its derivative, NO-naproxen, have focused primarily on chemically-induced ...
Apr 06, 2011 |
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Researchers find novel role for calcium channels in pacemaker cell function
Pacemaker cells in the sinoatrial node control heart rate, but what controls the ticking of these pacemaker cells? New research by Angelo Torrente and his colleagues of the M.E. Mangoni group's, reveals, for the first time, ...
Mar 09, 2011 |
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