News tagged with mutant p53 protein
Most common brain cancer may originate in neural stem cells
Jun 01, 2009 |
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University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points ...
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BBS proteins shown to run an export business that protects cilia
8 hours ago |
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A protein complex mutated in human disease removes excess signaling molecules to prevent them from damaging cilia, say researchers from UMass Medical School. The study will be published in the December 28 ...
Research yields new agent for some drug-resistant non-small cell lung cancers
Dec 23, 2009 |
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The ability to make, test, and map the atomic structure of new anti-cancer agents has enabled a team of Dana-Farber Cancer Institute scientists to discover a compound capable of halting a common type of drug-resistant ...
Subtle change dramatically reduces pathogenic potential of Huntington's protein
Dec 23, 2009 |
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Scientists have identified a key molecular switch that may drive the onset of Huntington's disease (HD), an incurable neurodegenerative disorder that leads to severe disruptions in muscle coordination and cognitive function. ...
IKK may act as both inhibitor and promoter of Huntington's disease
Dec 21, 2009 |
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The kinase IKK phosphorylates the protein mutated in Huntington's disease to promote its removal and neuron survival, but IKK may be a double-edged sword that increases neurotoxicity in later stages of the disease. The study, ...
Study explores 'garbage disposal' role of VCP and implications for degenerative disease
Dec 14, 2009 |
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It's important to finish what you start, say Jeong-Sun Ju and researchers from Washington University School of Medicine, St. Louis. In the December 14, 2009 issue of the Journal of Cell Biology, Ju et al. ...
Newly identified enzymes help plants sense elevated CO2 and could lead to water-wise crops
Dec 13, 2009 |
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Biologists have identified plant enzymes that may help to engineer plants that take advantage of elevated carbon dioxide to use water more efficiently. The finding could help to engineer crops that take advantage of rising ...
Researchers uncover chemical basis for extra 'quality control' in protein production
Dec 09, 2009 |
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December 9, 2009 -Even small errors made by cells during protein production can have profound disease effects, and nature has developed ways to uncover these mistakes and correct them. Though in the case of one essential ...
Elusive protein points to mechanism behind hearing loss
Medicine & Health / Neuroscience
Dec 08, 2009 |
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(PhysOrg.com) -- A serendipitous discovery of deaf zebra fish larvae has helped narrow down the function of an elusive protein necessary for hearing and balance. The work, led by Rockefeller University’s A. ...
New understanding of how to prevent destruction of a tumor suppressor
Dec 07, 2009 |
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Researchers from the Indiana University School of Medicine and colleagues at the University of Texas Southwestern and Case Western University have determined how the protein Mdm2, which is elevated in late-stage ...
Researchers restore some function to cells from cystic fibrosis patients
Dec 06, 2009 |
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In an encouraging new development, a team led by Scripps Research Institute scientists has restored partial function to lung cells collected from patients with cystic fibrosis. While there is still much work to be done before ...
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