News tagged with mutant protein
'Very promising' treatment for Huntington disease discovered
Medical researchers at the University of Alberta have discovered a promising new therapy for Huntington disease that restores lost motor skills and may delay or stop the progression of the disease based on lab model tests, ...
8 hours ago |
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Ultraviolet protection molecule in plants yields its secrets
Lying around in the sun all day is hazardous not just for humans but also for plants, which have no means of escape. Ultraviolet (UV) radiation from the sun can damage proteins and DNA inside cells, leading ...
Feb 09, 2012 |
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Gene linked to pancreatic cancer growth, study finds
A mutant protein found in nearly all pancreatic cancers plays a role not only in the cancer's development but in its continued growth, according to a new study from University of Michigan Comprehensive Cancer ...
Jan 31, 2012 |
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Disease progression halted in rat model of Lou Gehrig's disease
Amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig's disease) is an incurable adult neurodegenerative disorder that progresses to paralysis and death. Genetic mutations are the cause of disease in 5% of patients ...
Dec 12, 2011 |
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Characterizing a toxic offender
The brains of individuals with Alzheimer's disease contain protein aggregates called plaques and tangles, which interfere with normal communication between nerve cells and cause progressive learning and memory ...
Medicine & Health / Neuroscience
Dec 09, 2011 |
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Melatonin delays onset, reduces deaths in mouse model of Huntington's disease
Melatonin, best known for its role in sleep regulation, delayed the onset of symptoms and reduced mortality in a mouse model of Huntington's disease, say researchers at the University of Pittsburgh School of Medicine and ...
Medicine & Health / Neuroscience
Oct 11, 2011 |
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New insight into the cellular defects in Huntington's disease
Huntington disease is a devastating neurogenerative disorder that causes a progressive loss of functional capacity and reduced life span. It is an inherited condition caused by a mutant HTT gene. Although this has been known ...
Oct 10, 2011 |
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An 'unconventional' path to correcting cystic fibrosis
Researchers have identified an unconventional path that may correct the defect underlying cystic fibrosis, according to a report in the September 2nd issue of the journal Cell. This new treatment dramatically extends the li ...
Sep 01, 2011 |
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Molecular delivery truck serves gene therapy cocktail
In a kind of molecular gymnastics, scientists at the University of North Carolina at Chapel Hill School of Medicine have devised a gene therapy cocktail that has the potential to treat some inherited diseases associated with ...
Aug 15, 2011 |
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The genome guardian's dimmer switch: Regulating p53 is a matter of life or death
Scientists at the Salk Institute for Biological Studies have found clues to the functioning of an important damage response protein in cells. The protein, p53, can cause cells to stop dividing or even to commit suicide when ...
Jun 30, 2011 |
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Neutrons provide first sub-nanoscale snapshots of Huntington's disease protein
Researchers at the Department of Energy's Oak Ridge National Laboratory and the University of Tennessee have for the first time successfully characterized the earliest structural formation of the disease type ...
May 18, 2011 |
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Researchers make strides in understanding amyotrophic lateral sclerosis
Brandeis researchers have made a significant advance in the effort to understand amyotrophic lateral sclerosis (ALS) by successfully reversing the toxicity of the mutated protein in the familial type of the ...
Apr 26, 2011 |
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Huntington's disease protein has broader effects on brain, study shows
In Huntington's disease, the mutant protein known as huntingtin leads to the degeneration of a part of the brain known as the basal ganglia, causing the motor disturbances that represent one of the most defining features ...
Apr 05, 2011 |
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Mutant prions help cells foil harmful protein misfolding
Romping clumps of misfolded proteins are prime suspects in many neurological disorders including Alzheimer's, Parkinson's, and Creutzfeld-Jakob Disease. Those diseases are devastating and incurable, but a team of biologists ...
Mar 20, 2011 |
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Study traces possible role of damaged DNA in tumor development
DNA provides the instruction manual for all life forms. Occasionally, instructions are not carried out properly, and bad messages are sent leading to the creation of mutant proteins and possible tumor development.
Mar 04, 2011 |
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