News tagged with mutant protein
Just a little squeeze lets proteins assess DNA
Biology /
Dec 16, 2008 |
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(PhysOrg.com) -- To find its target, all a protein needs to do is give quick squeezes as it moves along the DNA strand, suggests new research from The University of Arizona in Tucson.
Mighty mice: Treatment targeted to muscle improves motor neuron disease
Medicine & Health / Neuroscience
Aug 12, 2009 |
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New research with transgenic mice reveals that a therapy directed at the muscle significantly improves disease symptoms of a genetic disorder characterized by destruction of the neurons that control movement. The study, published ...
Modification of mutant huntingtin protein increases its clearance from brain cells
Apr 02, 2009 |
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A new study has identified a potential strategy for removing the abnormal protein that causes Huntington's disease (HD) from brain cells, which could slow the progression of the devastating neurological disorder. In the ...
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'Intrabody' can mop up mutant protein in Huntington's disease model
May 26, 2008 |
4.8 / 5 (5) |
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Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington's disease. Emory University researchers engineered a virus to make an intracellular antibody or "intrabody" ...
Stabilizing cancer-fighting p53 can also shield a metastasis-promoter
May 22, 2008 |
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Efforts to protect the tumor-suppressor p53 could just as easily shelter a mutant version of the protein, causing cancer cells to thrive and spread rather than die, according to research by scientists at The University of ...
Mutant host cell protein sequesters critical HIV-1 element
Medicine & Health / HIV & AIDS
Jan 15, 2009 |
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Scientists have identified a new way to inhibit a molecule that is critical for HIV pathogenesis. The research, published by Cell Press in the January 16th issue of the journal Molecular Cell, presents a target for develo ...
Chemopreventive isothiocyanates selectively depletes mutant p53 in tumor cells
Apr 20, 2009 |
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Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have demonstrated that naturally-occurring compounds can selectively deplete mutant p53 and restore "wild type" function to p53 in ...
Researchers identify new, cancer-causing role for protein
Aug 27, 2009 |
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The mainstay immune system protein TRAF6 plays an unexpected, key role activating a cell signaling molecule that in mutant form is associated with cancer growth, researchers at The University of Texas M. D. ...
Mutant proteins result in infectious prion disease in mice
Biology /
Dec 05, 2008 |
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A worldwide group of scientists has created an infectious prion disease in a mouse model, in a step that may help unravel the mystery of this progressive disease that affects the nervous system in humans and animals. The ...
Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
Medicine & Health / Neuroscience
Jun 19, 2009 |
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A Japanese research group, led by Dr. Yoko Yamagata of the National Institute for Physiological Sciences, has successfully generated a novel kinase-dead mutant mouse of the CaMKIIalpha gene that completely and exclusively ...
Promising new treatment for Alzheimer's suggested
Jul 20, 2009 |
4 / 5 (1) |
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Research carried out at the Hebrew University of Jerusalem has resulted in a promising approach to help treat Alzheimer's disease in a significant proportion of the population that suffers from a particularly rapid development ...
Mutant gene's true effect revealed - giving new therapy hope
Oct 19, 2009 |
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(PhysOrg.com) -- Scientists have revealed how a mutant gene that causes a connective tissue disease resulting in dwarfism does so by significantly affecting the inside of cells - opening up new therapy strategies that involve ...
Model for angelman syndrome developed
Aug 14, 2008 |
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A model for studying the genetics of Angelman syndrome, a neurological disorder that causes mental retardation and other symptoms in one out of 15,000 births, has been developed by biologists at The University of Texas at ...
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