News tagged with notch signaling pathway
Fate in fly sensory organ precursor cells could explain human immune disorder
Jun 21, 2009 |
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(June 21, 2009) - Notch signaling helps determine the fate of a number of different cell types in a variety of organisms, including humans. In an article that appears in the current issue of Nature Cell Biology, researchers at Bay ...
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'Notch'ing up a role in the multisystem disease tuberous sclerosis complex
6 hours ago |
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Two independent teams of researchers have identified a role for enhanced activation of the signaling protein Notch in tumors characterized by inactivation of either the TSC1 or the TSC2 protein. As indicated by Warren Pear, ...
Developing cancer treatments directed at critical developmental pathway
Biology /
Apr 10, 2008 |
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Researchers from the University of Pennsylvania School of Medicine and colleagues discovered that the Notch signaling pathway, which determines the development of many cell types, and is also implicated in some cancers, is ...
Top notch decisions in the developing airways bring insights into lung disease
Jun 08, 2009 |
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In the normal lung, the airways are lined by a balanced mixture of ciliated, secretory and neuroendocrine cells which perform functions as diverse as air humidification, detoxification, and clearance of environmental particles. ...
Discovery makes brain tumor cells more responsive to radiation
Dec 02, 2009 |
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Duke University Medical Center researchers have figured out how stem cells in the malignant brain cancer glioma may be better able to resist radiation therapy. And using a drug to block a particular signaling pathway in these ...
Discovery could lead to much-needed kidney failure treatment
Mar 12, 2008 |
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The unwanted activation of an important cell-signaling pathway may play a role in two kidney problems that are major causes of end-stage renal disease, scientists at the Albert Einstein College of Medicine of Yeshiva University ...
New therapeutic target identified for rheumatoid arthritis
Nov 05, 2008 |
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Researchers at Hospital for Special Surgery have identified a potential new therapeutic target that could be used to treat inflammatory disorders, such as rheumatoid arthritis.
From fruit fly wings to heart failure -- why Not(ch)?
Dec 10, 2009 |
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Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published ...
Notch controls bone formation and strength
Feb 24, 2008 |
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Notch, a protein known to govern the determination of cell differentiation into different kinds of tissues in embryos, plays a critical role in bone formation and strength later in life, said researchers from Baylor College ...
Gene is likely cause of stroke-inducing vascular malformations
Sep 02, 2008 |
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UCSF scientists have discovered that a gene controlling whether blood vessels differentiate into arteries or veins during embryonic development is linked to a vascular disorder in the brain that causes stroke.
Neural stem cell differentiation factor discovered
Jun 30, 2009 |
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Neural stem cells represent the cellular backup of our brain. These cells are capable of self-renewal to form new stem cells or differentiate into neurons, astrocytes or oligodendrocytes. Astrocytes have supportive functions ...
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