News tagged with null mice
Research reveals mechanism linking serotonin with regulation of food intake
Nov 26, 2008 |
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Genetic mouse models have provided surprising insight into mechanisms linking serotoninergic compounds with the regulation of feeding behavior and body weight. The research, published by Cell Press in the November 26th issue ...
Clue to genetic cause of fatal birth defect
Oct 09, 2008 |
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A novel enzyme may play a major role in anencephaly, offering hope for a genetic test or even therapy for the rare fatal birth defect in which the brain fails to develop, according to a study from researchers at the University ...
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Tumor-initiating Cells Detected in Pten Null Prostate Cancer Model
Nov 12, 2009 |
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(PhysOrg.com) -- New findings published in Cancer Research, a journal of the American Association for Cancer Research, advance the current understanding of the role of stem/progenitor cells on the initiation and progression of pro ...
Researchers have immune cells running in circles
Nov 02, 2009 |
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(PhysOrg.com) -- University of Illinois at Chicago College of Medicine researchers have identified the important role a protein plays in the body's first line of defense in directing immune cells called neutrophils toward ...
Inflammation contributes to colon cancer
Jan 21, 2009 |
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Researchers led by Drs. Lillian Maggio-Price and Brian Iritani at The University of Washington found that mice that lack the immune inhibitory molecule Smad3 are acutely sensitive to both bacterially-induced inflammation ...
Mouse model provides a new tool for investigators of human developmental disorder
Apr 21, 2009 |
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Wolf-Hirschhorn Syndrome (WHS) is a human disease caused by spontaneous genetic deletions. Children born with WHS have a characteristic set of facial features, including a wide flat nose bridge, downturned mouth, high forehead, ...
Immaturity of the brain may cause schizophrenia
Sep 10, 2008 |
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The underdevelopment of a specific region in the brain may lead to schizophrenia in individuals. According to research published today in BioMed Central's open access journal Molecular Brain, dentate gyrus, which is locate ...
Scientists discover master regulator of motor neuron firing
Medicine & Health / Neuroscience
Mar 16, 2009 |
4.7 / 5 (3) |
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(PhysOrg.com) -- When the Human Genome Project was complete, DNA bowed out of the limelight and gave way to RNA as a major player in genetic regulation. Now, findings at Rockefeller University mirror this ...
Distinguishing Friend from Foe in the Battle Against Cancer
Sep 11, 2006 |
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The latest generation of cancer chemotherapeutic drugs specifically targets mutant enzymes or “oncoproteins” that have run amok and now promote uncontrolled cell growth. As promising as these drugs are, cancer cells with ...
Of mice and men: Stem cells and ethical uncertainties
Oct 29, 2009 |
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The recent creation of live mice from induced pluripotent stem cells (iPSCs) not only represents a remarkable scientific achievement, but also raises important issues, according to bioethicists at The Johns Hopkins University's ...
Paper sheds new 'light' on fascinating rhythms of the circadian clock
Biology /
Feb 16, 2009 |
4.6 / 5 (7) |
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(PhysOrg.com) -- Scientists have long known that interrupting the 24-hour circadian rhythm plays havoc with the lives and health of medical, military and airline personnel, factory employees and travelers.
Gene knockout may cheer up mice
Medicine & Health / Neuroscience
Nov 12, 2009 |
3 / 5 (2) |
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Removing the PKCI/HINT1 gene from mice has an anti-depressant-like and anxiolytic-like effect. Researchers writing in the open access journal BMC Neuroscience applied a battery of behavioral tests to the PKCI/HINT1 knocko ...
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