Oncogene
hideAn oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a cancer cell.
Many cells normally undergo a programmed form of death (apoptosis). Activated oncogenes can cause those cells to survive and proliferate instead. Most oncogenes require an additional step, such as mutations in another gene, or environmental factors, such as viral infection, to cause cancer. Since the 1970s, dozens of oncogenes have been identified in human cancer. Many cancer drugs target those DNA sequences and their products.
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News tagged with oncogene
New research shows versatility of amniotic fluid stem cells
Nov 23, 2009 |
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For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of ...
Revealing cancers' weak spots: Researchers exploit genetic 'co-dependence' to kill treatment-resistant tumor cells
Oct 20, 2009 |
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(PhysOrg.com) -- Cancer cells fueled by the mutant KRAS oncogene, which makes them notoriously difficult to treat, can be killed by blocking a more vulnerable genetic partner of KRAS, report scientists at ...
Scientists pinpoint breast cancer 'guard' gene
Oct 06, 2009 |
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(PhysOrg.com) -- Scientists are close to discovering how normal breast cells become cancerous, according to research by Cambridge scientists published today.
Lung cancer oncogene holds key to turning off cancer stem cells
Sep 08, 2009 |
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Scientists at the Mayo Clinic campus in Florida have found that the lung cancer oncogene PKCiota is necessary for the proliferation of lung cancer stem cells. These stem cells are rare and powerful master cells that manufacture ...
New Hope for Deadly Childhood Bone Cancer
Aug 31, 2009 |
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(PhysOrg.com) -- Researchers at Huntsman Cancer Institute (HCI) at the University of Utah have shed new light on Ewing’s sarcoma, an often deadly bone cancer that typically afflicts children and young adults. Their research ...
New prognostic marker for human breast cancer
Aug 24, 2009 |
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Elevated levels of GLI1 (glioma-associated oncogene homolog 1) protein in human breast cancer are associated with unfavorable prognosis and progressive stages of disease. Researchers writing in the open access journal BMC Ca ...
Antibody targeting of glioblastoma shows promise in preclinical tests
Jul 31, 2009 |
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Cancer researchers at Georgetown University's Lombardi Comprehensive Cancer Center have successfully tested a small, engineered antibody they say shuts down growth of human glioblastoma tumors in cell and animal studies. ...
Study identifies first molecular steps to childhood leukemia
Jul 15, 2009 |
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A Massachusetts General Hospital (MGH)-based research team has identified how a chromosomal abnormality known to be associated with acute lymphoblastic leukemia (ALL) - the most common cancer in children - initiates the disease ...
Hitting where it hurts: Exploiting cancer cell 'addiction' may lead to new therapies
Jun 01, 2009 |
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A new study uncovers a gene expression signature that reliably identifies cancer cells whose survival is dependent on a common signaling pathway, even when the cells contain multiple other genetic abnormalities. The research, ...
New melanoma tumor suppressor gene uncovered
Mar 29, 2009 |
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National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a s ...
New discovery raises doubts about current bladder treatment
Mar 25, 2009 |
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Researchers at the University of Virginia Health System have found that one of the genes commonly thought to promote the growth and spread of some types of cancers is in fact beneficial in bladder cancer - a major discovery ...
Study finds new risk factor for melanoma in younger women
Mar 24, 2009 |
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Researchers may have found a more potent risk factor for melanoma than blistering sunburns, freckling, or family history of the deadly skin disease. In a new study, scientists at NYU Langone Medical Center report that a genetic ...
Cancer: Another step towards medication
Mar 18, 2009 |
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The Myc-gene plays an important role in cell regulation; in about 50 percent of all tumors this gene is mutated. Scientists led by Professor Klaus Bister of the University of Innsbruck, Austria have shown ...
