Osteoarthritis
hideOsteoarthritis (OA, also known as degenerative arthritis, degenerative joint disease), is a group of diseases and mechanical abnormalities entailing degradation of joints, including articular cartilage and the subchondral bone next to it. Clinical symptoms of OA may include joint pain, tenderness, stiffness, inflammation, creaking, and locking of joints. In OA, a variety of potential forces—hereditary, developmental, metabolic, and mechanical—may initiate processes leading to loss of cartilage -- a strong protein matrix that lubricates and cushions the joints. As the body struggles to contain ongoing damage, immune and regrowth processes can accelerate damage. When bone surfaces become less well protected by cartilage, subchondral bone may be exposed and damaged, with regrowth leading to a proliferation of ivory-like, dense, reactive bone in central areas of cartilage loss, a process called eburnation. The patient increasingly experiences pain upon weight bearing, including walking and standing. Due to decreased movement because of the pain, regional muscles may atrophy, and ligaments may become more lax. OA is the most common form of arthritis, and the leading cause of chronic disability in the United States.
"Osteoarthritis" is derived from the Greek word "osteo", meaning "of the bone", "arthro", meaning "joint", and "itis", meaning inflammation, although many sufferers have little or no inflammation. Osteoarthritis is not to be confused with rheumatoid arthritis, an inflammatory joint disease. A common misconception is that OA is due solely to wear and tear, since OA typically is not present in younger people. However, while age is correlated with OA incidence, this correlation merely illustrates that OA is a process that takes time to develop. There is usually an underlying cause for OA, in which case it is described as secondary OA. If no underlying cause can be identified it is described as primary OA. "Degenerative arthritis" is often used as a synonym for OA, but the latter involves both degenerative and regenerative changes.
OA affects nearly 27 million people in the United States, accounting for 25% of visits to primary care physicians, and half of all NSAID (Non-Steroidal Anti-Inflammatory Drugs) prescriptions. It is estimated that 80% of the population will have radiographic evidence of OA by age 65, although only 60% of those will show symptoms. In the United States, hospitalizations for osteoarthritis soared from about 322,000 in 1993 to 735,000 in 2006.
For more information about Osteoarthritis, read the full article at
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News tagged with osteoarthritis
Osteoarthritis increases aggregate health care expenditures by $186 billion annually
Nov 30, 2009 |
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Osteoarthritis (OA), a highly prevalent disease, raised aggregate annual medical care expenditures in the U.S. by $185.5 billion according to researchers from Stony Brook University. Insurers footed $149.4 billion of the ...
Researchers discover Hedgehogs could play a role in treating osteoarthritis
Nov 17, 2009 |
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(PhysOrg.com) -- Researchers at the University of Toronto and the Hospital for Sick Children (SickKids) have found a pharmacological approach to treating the disease. The study is published in the November 15 advance online ...
Study finds link between childhood physical abuse and arthritis
Nov 02, 2009 |
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Adults who had experienced physical abuse as children have 56 per cent higher odds of osteoarthritis compared to those who have not been abused, according to a new study by University of Toronto researchers.
Growing Cartilage from Stem Cells
Oct 20, 2009 |
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(PhysOrg.com) -- Damaged knee joints might one day be repaired with cartilage grown from stem cells in a laboratory, based on research by Professor Kyriacos Athanasiou, chair of the UC Davis Department of Biomedical Engineering ...
Scientists find cause of cartilage degeneration in osteoarthritis
Jan 12, 2009 |
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The scientists describe their work in this week's Early Edition of the Proceedings of the National Academy of Sciences. In the study, the team shows how the loss of the protein HMGB2, found in the surface layer of joint ...
Hormone promises to keep joint injuries from causing long-term osteoarthritis
Sep 12, 2009 |
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An existing osteoporosis drug is the first ever found to prevent cartilage loss from osteoarthritis following injury to a joint, and may also regenerate some cartilage that has been lost to osteoarthritis, according to an ...
Jellyfish protein helps regrow joint cartilage
Feb 07, 2009 |
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Mucin, a protein extracted from Nomura's jellyfish, has proved highly effective in regrowing cartilage in joints, scientists in Japan claim.
Trial raises doubts over alternative pain therapy for arthritis
Oct 16, 2009 |
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Copper bracelets and magnetic wrist straps are ineffective in relieving arthritis pain, according to a new study led by a University of York academic.
Research shows Tai Chi exercise reduces knee osteoarthritis pain in the elderly
Oct 29, 2009 |
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Researchers from Tufts University School of Medicine have determined that patients over 65 years of age with knee osteoarthritis (OA) who engage in regular Tai Chi exercise improve physical function and experience less pain. ...
Veterinarians using stem cells to treat animals
Aug 10, 2009 |
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(AP) -- Lucy the Labradoodle scoots along the ground to grab a bone.
Scientists Find Obesity Alone Does Not Cause Arthritis in Animals
Sep 29, 2009 |
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(PhysOrg.com) -- The link between obesity and osteoarthritis may be more than just the wear and tear on the skeleton caused by added weight.
Moderate weight loss helps reduce risk of osteoarthritis in the knee
Oct 19, 2009 |
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(PhysOrg.com) -- Here’s another good reason to lose even a moderate amount of weight: it could reduce your risk of developing osteoarthritis in your knees.
TENS for osteoarthritis: Not enough evidence to recommend
Oct 07, 2009 |
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Despite twenty years of research on the use of electrostimulation techniques (TENS) for treatment of osteoarthritis in the knee, researchers still cannot say whether it reduces pain or physical disability. This is the conclusion ...
Cognitive behavioral therapy improves sleep and pain in people with osteoarthritis
Aug 16, 2009 |
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A study in the Aug. 15 issue of the Journal of Clinical Sleep Medicine shows that the use of cognitive behavioral therapy for insomnia (CBT-I) is an effective treatment for older patients with osteoarthritis and comorbid insomn ...
Women with strong thigh muscles protected from symptomatic knee osteoarthritis
Aug 27, 2009 |
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A new study by researchers at the University of Iowa Hospitals and Clinics found that thigh muscle strength does not predict the occurrence of knee osteoarthritis (OA) uncovered in x-rays, but does predict incidence of painful ...
