News tagged with p53 function
The 2 faces of Mdmx: Why some tumors don't respond to radiation and chemotherapy
Jul 06, 2009 |
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A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells. In their latest study, ...
Search results for p53 function
Effect of mutant p53 stability on tumorigenesis and drug design
May 15, 2008 |
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In the May 15th issue of G&D, Dr. Guillermina Lozano (MD Anderson Cancer Center) and colleagues reveal how the stabilization of a mutated form of p53 affects oncogenesis, and lends startling new insight into the potential ...
Chemopreventive isothiocyanates selectively depletes mutant p53 in tumor cells
Apr 20, 2009 |
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Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have demonstrated that naturally-occurring compounds can selectively deplete mutant p53 and restore "wild type" function to p53 in ...
Protein can help cells or cause cancer, researcher finds
Jul 07, 2009 |
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A Purdue University scientist has discovered a key process in cell growth that can lead to the formation of tumors.
Stabilizing cancer-fighting p53 can also shield a metastasis-promoter
May 22, 2008 |
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Efforts to protect the tumor-suppressor p53 could just as easily shelter a mutant version of the protein, causing cancer cells to thrive and spread rather than die, according to research by scientists at The University of ...
Research shows cell's inactive state is critical for effectiveness of cancer treatment
Biology /
Jan 09, 2009 |
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A new study sheds light on a little understood biological process called quiescence, which enables blood-forming stem cells to exist in a dormant or inactive state in which they are not growing or dividing. According to the ...
How eating fruit and vegetables can improve cancer patients' response to chemotherapy
Oct 22, 2008 |
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The leading cause of death in all cancer patients continues to be the resistance of tumor cells to chemotherapy, a form of treatment in which chemicals are used to kill cells.
Breast cancer drug shows promise for treating, preventing progestin-dependent tumors
Jan 28, 2009 |
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Recent studies suggest that human breast cancer risk is increased by outside exposure to the hormone progestin, such as during hormone replacement therapy. Now, a University of Missouri study suggests that PRIMA-1, a small ...
Penn researchers find diabetes drug kills some cancer cells
Aug 14, 2007 |
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Researchers at the University of Pennsylvania School of Medicine have found that a commonly prescribed diabetes drug kills tumor cells that lack a key regulatory gene called p53. Results from current studies in mice may result ...
Tumor mutations can predict chemo success
Aug 06, 2009 |
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(PhysOrg.com) -- New work by MIT cancer biologists shows that the interplay between two key genes that are often defective in tumors determines how cancer cells respond to chemotherapy.
Researchers discover how tumor suppressor inhibits cell growth
Aug 07, 2008 |
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Genes that inhibit the spontaneous development of cancer are called tumor suppressor genes. One of the major tumor suppressors is p53, a protein that acts in the cell nucleus to control the expression of other genes whose ...
List of search results for p53 function
