News tagged with p53 mutation
Study gives clues to how adrenal cancer forms
Jun 04, 2009 |
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At the ends of chromosome are special pieces of DNA called telomeres. Think of it as the little tip that caps off a shoelace. The telomeres send signals to the cells to let them know it's the end point, not ...
Large study documents how p53 mutations link to high-grade breast cancer, poor outcomes
Apr 19, 2009 |
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In what is believed to be the largest study of its kind in the US, researchers have found that almost 26 percent of women studied who have breast cancer have mutations in a gene important in controlling cell growth and death, ...
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Stabilizing cancer-fighting p53 can also shield a metastasis-promoter
May 22, 2008 |
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Efforts to protect the tumor-suppressor p53 could just as easily shelter a mutant version of the protein, causing cancer cells to thrive and spread rather than die, according to research by scientists at The University of ...
Effect of mutant p53 stability on tumorigenesis and drug design
May 15, 2008 |
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In the May 15th issue of G&D, Dr. Guillermina Lozano (MD Anderson Cancer Center) and colleagues reveal how the stabilization of a mutated form of p53 affects oncogenesis, and lends startling new insight into the potential ...
Novel model of osteosarcoma
Jun 15, 2008 |
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In the June 15th issue of G&D, Dr. Stuart Orkin (HHMI, Dana-Farber Cancer Institute, Children's Hospital Boston) and colleagues present a new mouse model of osteosarcoma.
A breakthrough in gastric carcinogenesis
Jun 11, 2009 |
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Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to ...
Loss of Tumor-Suppressor and DNA-Maintenance Proteins Causes Tissue Demise, Study Finds
Oct 15, 2009 |
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(PhysOrg.com) -- A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrup ...
Estrogen can reduce stroke damage by inactivating protein
Jul 16, 2009 |
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Estrogen can halt stroke damage by inactivating a tumor-suppressing protein known to prevent many cancers, Medical College of Georgia researchers say.
Antitumor activity of nutlin-3 in neuroblastoma with wild-type p53
Nov 10, 2009 |
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The small-molecule inhibitor nutlin-3 may be a viable treatment option for neuroblastoma patients with wild-type p53 activity, according to a new study published online November 10 in the Journal of the National Cancer In ...
Tumor mutations can predict chemo success
Aug 06, 2009 |
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(PhysOrg.com) -- New work by MIT cancer biologists shows that the interplay between two key genes that are often defective in tumors determines how cancer cells respond to chemotherapy.
Penn researchers find diabetes drug kills some cancer cells
Aug 14, 2007 |
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Researchers at the University of Pennsylvania School of Medicine have found that a commonly prescribed diabetes drug kills tumor cells that lack a key regulatory gene called p53. Results from current studies in mice may result ...
Study of placenta unexpectedly leads to cancer gene
Dec 16, 2008 |
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University of Rochester Medical Center scientists discovered a gene mutation that impairs the placenta and also is influential in cancer development, according to a study published online December 16, 2008, in the journal ...
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