News tagged with p53 mutation
DGK-alpha helps cancer cells gain traction and mobilize
Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology reveals how a lipid-converting enzyme helps the cells mobilize these integrins.
Jan 23, 2012 |
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Gene found to play role in early cancer
(Medical Xpress) -- Mutations to a gene called p53 have been linked to half of all cancers, leading to tumor growth and the spread of cancerous cells. Now, a Cornell-led study identifies for the first time the mechanisms ...
Aug 24, 2011 |
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Cancer cells and stem cells share same origin: study
Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells. Scientists at the Keck School of Medicine of the University of Southern California (USC) have proven that those ...
Jul 18, 2011 |
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Gene fault could predict ovarian cancer drug success
Faults in a gene commonly inactivated in many different types of cancer could be used to predict which drug combination ovarian cancer patients are most likely to benefit from, according to research at Newcastle University.
Jun 06, 2011 |
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Cancer is a p53 protein aggregation disease
Protein aggregation, generally associated with Alzheimer's and mad cow disease, turns out to play a significant role in cancer. In a paper published in Nature Chemical Biology, Frederic Rousseau and Joost Schymkowitz of VIB ...
Mar 29, 2011 |
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Small molecule may disarm enemy of cancer-fighting p53
A pioneering clinical trial is testing the effectiveness in leukemia of a small molecule that shuts down MDM2, a protein that can disable the well-known tumor suppressor p53.
Dec 07, 2010 |
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Restoring the gene for cancer protein p53 slows spread of advanced tumors
(PhysOrg.com) -- In a new study to be published in the Nov. 25 issue of Nature, MIT cancer biologists show that restoring the protein p53's function in mice with lung cancer has no effect early in tumor develo ...
Nov 24, 2010 |
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New function discovered in cancer prevention protein
Protein 53 is very important in protecting against cancer given that it prevents cancer-causing mutations from accumulating and its inactivation is closely linked to the proliferation of tumour cells. UAB (Universitat Autonoma ...
Jun 07, 2010 |
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Researchers find a weak link in cancer cell armor
(PhysOrg.com) -- Professor Robert Weiss has found that when two particular genes are inhibited, cancer cells are destroyed at a greater rate. The study is published in the Nov. 9 issue of PNAS.
Nov 11, 2009 |
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Study shows that some malignant tumors can be shut down after all
Oncologists have had their hands tied because more than half of all human cancers have mutations that disable a protein called p53. As a critical anti-cancer watchdog, p53 masterminds several cancer-fighting operations within ...
Nov 09, 2009 |
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Singapore scientists discover widely sought molecular key to understanding p53 tumor suppressor gene
Scientists at the Singapore Immunology Network (SIgN) have determined how the master gene regulator p53 could switch a gene in a cell "on" or "off" by recognizing specific sequences of nucleotides in the gene's DNA.
Oct 13, 2009 |
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Tumor mutations can predict chemo success
(PhysOrg.com) -- New work by MIT cancer biologists shows that the interplay between two key genes that are often defective in tumors determines how cancer cells respond to chemotherapy.
Aug 06, 2009 |
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Study gives clues to how adrenal cancer forms
At the ends of chromosome are special pieces of DNA called telomeres. Think of it as the little tip that caps off a shoelace. The telomeres send signals to the cells to let them know it's the end point, not ...
Jun 04, 2009 |
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Most common brain cancer may originate in neural stem cells
University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points ...
Jun 01, 2009 |
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Large study documents how p53 mutations link to high-grade breast cancer, poor outcomes
In what is believed to be the largest study of its kind in the US, researchers have found that almost 26 percent of women studied who have breast cancer have mutations in a gene important in controlling cell growth and death, ...
Apr 19, 2009 |
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