News tagged with polymerase

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Gene transcribing machine takes halting, backsliding trip along the DNA

Gene transcribing machine takes halting, backsliding trip along the DNA

Chemistry / Biochemistry

created Jul 30, 2009 | popularity 5 / 5 (4) | comments 1

(PhysOrg.com) -- The body's nanomachines that read our genes don't run as smoothly as previously thought, according to a new study by University of California, Berkeley, scientists.


'Sloppier copier' surprisingly efficient

Biology / Cell & Microbiology

created Jul 15, 2009 | popularity 4.3 / 5 (4) | comments 3

The "sloppier copier" discovered by USC biologists is also the best sixth man in the DNA repair game, an article in the journal Nature shows.


A Real Dracula Story

Biology / Cell & Microbiology

created Aug 27, 2009 | popularity 4.8 / 5 (4) | comments 0

Research, discovery and publishing in a prestigious journal are not as easy as 1-2-3. However, an outstanding mentor and a well-equipped lab made this feat possible for doctoral student Fei Jiang.


Monitoring Cancer Cell Changes With Quantum Dots

Nanotechnology / Bio & Medicine

created Jul 23, 2009 | popularity 5 / 5 (1) | comments 0

One of the earliest events that changes a normal cell into a malignant one is known as deoxyribonucleic acid (DNA) hypermethylation, a biochemical alteration that inactivates critical tumor-suppressor genes. A team of investigators ...


One secret to how TB sticks with you

Biology / Cell & Microbiology

created Jul 09, 2009 | popularity 3 / 5 (2) | comments 0

Mycobacterium tuberculosis is arguably the world's most successful infectious agent because it knows how to avoid elimination by slowing its own growth to a crawl. Now, a report in the July 10 issue of the journal Cell, ...


Faster, more cost-effective DNA test for crime scenes, disease diagnosis

Faster, more cost-effective DNA test for crime scenes, disease diagnosis

Chemistry / Analytical Chemistry

created Jul 08, 2009 | popularity 4 / 5 (1) | comments 0

Scientists in Japan are reporting development of a faster, less expensive version of the fabled polymerase chain reaction (PCR) a DNA test widely used in criminal investigations, disease diagnosis, biological ...


Molecular typesetting -- proofreading without a proofreader

Biology / Cell & Microbiology

created Jun 23, 2009 | popularity 5 / 5 (1) | comments 0

Researchers at the Universities of Leeds and Bristol (UK) have developed a model of how errors are corrected whilst proteins are being built.


New piece found in the puzzle of epigenetics

Biology / Cell & Microbiology

created Jun 16, 2009 | popularity 5 / 5 (8) | comments 0

For many years scientists have known that the numerous biological functions of an organism are not regulated solely by the DNA sequence of its genes: Superordinate regulatory mechanisms exist that contribute to determining ...


Researchers Reveal Structure of Key Genetic Proofreading Protein

Researchers Reveal Structure of Key Genetic Proofreading Protein

Chemistry / Biochemistry

created Jun 05, 2009 | popularity 5 / 5 (2) | comments 0

(PhysOrg.com) -- Nature might abhor a vacuum, but it loves a backup plan. In living organisms, physiological systems are kept under tight control by hierarchies of organic safety catches and emergency releases, ...


Researchers study virus with unusual properties

Researchers study virus with unusual properties

Biology /

created Dec 08, 2008 | popularity 4.7 / 5 (14) | comments 0

(PhysOrg.com) -- A team of researchers from Penn State University and the University of Chicago has uncovered clues that may explain how and why a particular virus, called N4, injects an unusual substance ...


How 'molecular machines' kick start gene activation revealed

Biology /

created Nov 06, 2008 | popularity 4.8 / 5 (4) | comments 0

How 'molecular machines' inside cells swing into action to activate genes at different times in a cell's life is revealed today in new research published in Molecular Cell.


Study Shows How Antibiotic Sets Up Road Block To Kill Bacteria

Chemistry /

created Oct 23, 2008 | popularity 5 / 5 (6) | comments 0

(PhysOrg.com) -- Scientists have taken a critical step toward the development of new and more effective antibacterial drugs by identifying exactly how a specific antibiotic sets up a road block that halts bacterial growth.


Study shows how antibiotic sets up road block to kill bacteria

Biology /

created Oct 22, 2008 | popularity 5 / 5 (10) | comments 0

Scientists have taken a critical step toward the development of new and more effective antibacterial drugs by identifying exactly how a specific antibiotic sets up a road block that halts bacterial growth.


Molecule stops DNA replication in its tracks

Molecule stops DNA replication in its tracks

Biology /

created Oct 20, 2008 | popularity 4 / 5 (3) | comments 0

(PhysOrg.com) -- When a dividing cell duplicates its genetic material, a molecular machine called a sliding clamp travels along the DNA double helix, tethering the proteins that perform the replication. Researchers ...


E. coli discovery could lead to new antibacterial target

Chemistry /

created Jul 29, 2008 | popularity 4.5 / 5 (4) | comments 0

Northeastern University scientists have discovered a new and unique DNA binding property of a protein in E. coli. Penny J. Beuning, Assistant Professor in the Department of Chemistry and Chemical Biology, spent the last two ...