PRNP
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PRNP (PRioN Protein (Creutzfeld-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia)) is a gene that codes for a protein called the prion protein (PrP), which is expressed in the brain and several other tissues.
The human PRNP gene is located on the short (p) arm of chromosome 20 between the end (terminus) of the arm and position 12, from base pair 4,615,068 to base pair 4,630,233.
PRNP has also recently been designated CD230 (cluster of differentiation 230).
For more information about PRNP, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
News tagged with prion protein
Researchers find new piece of BSE puzzle
Nov 20, 2009 |
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A new treatment route for bovine spongiform encephalopathy (BSE) and its human form Creutzfeldt Jakob disease (CJD) could be a step closer based on new results from scientists at the University of Leeds. The team has found ...
Scientists uncover evolutionary origins of prion disease gene
Sep 28, 2009 |
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A University of Toronto-led team has uncovered the evolutionary ancestry of the prion gene, which may reveal new understandings of how the prion protein causes diseases such as bovine spongiform encephalopathy (BSE), also ...
Study points to disruption of copper regulation as key to prion diseases
Apr 17, 2009 |
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(PhysOrg.com) -- An investigation of a rare, inherited form of Creutzfeldt-Jakob disease suggests that disrupted regulation of copper ions in the brain may be a key factor in this and other prion diseases.
Prion discovery gives clue to control of mass gene expression
Mar 13, 2009 |
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The discovery in common brewer's yeast of a new, infectious, misfolded protein -- or prion -- by University of Illinois at Chicago molecular biologists raises new questions about the roles played by these curious molecules, ...
Iron is involved in prion disease-associated neuronal demise
Mar 13, 2009 |
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Imbalance of iron homeostasis is a common feature of prion disease-affected human, mouse, and hamster brains, according to a new study by Dr. Neena Singh and colleagues at Case Western Reserve University School of Medicine, ...
What drove the cow mad? Lessons from a tiny fish
Mar 10, 2009 |
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For over twenty years, scientists have known that a normal protein in the brain, PrP, or prion protein, can turn harmful and cause deadly illnesses like Creutzfeldt-Jakob disease (CJD) in humans, and bovine spongiform encephalopathy ...
Sticky antibodies block prion disease
Biology /
Feb 12, 2009 |
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(PhysOrg.com) -- Antibodies that stick to a brain prion protein called PrP could be the key to treating prion diseases like variant CJD and preventing people accidentally exposed to prions from going on to ...
Mutant proteins result in infectious prion disease in mice
Biology /
Dec 05, 2008 |
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A worldwide group of scientists has created an infectious prion disease in a mouse model, in a step that may help unravel the mystery of this progressive disease that affects the nervous system in humans and animals. The ...
Tracking Down the Cause of Mad Cow Disease
Oct 07, 2008 |
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(PhysOrg.com) -- The cause of diseases such as BSE in cattle and Creutzfeld–Jakob disease in humans is a prion protein. This protein attaches to cell membranes by way of an anchor made of sugar and lipid components ...
Is there more to prion protein than mad cow disease?
Sep 30, 2008 |
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Prion protein, a form of protein that triggers BSE, is associated with other brain diseases in cattle, raising the possibility of a significant increase in the range of prion disease. Publishing their findings in the open ...
A novel approach in the molecular differentiation of prion strains
Biology /
Aug 29, 2008 |
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A team from the French Food Safety Agency, Lyon, France, has identified a prion protein characteristic that is unique to some natural but unusual sheep scrapie cases. This finding, reported August 29th in the open-access ...
