Aging leads to a decline in cellular fitness and loss of optimal protein function. Many age-related ailments, including Alzheimer's and Parkinson's diseases, are caused by protein aggregation, a result of errors in protein ...
Molecular & Computational biology
Jan 19, 2022
0
73
Rutgers researchers have discovered some of the first molecular insights into how toxic proteins are regulated in neurodegenerative diseases such as Alzheimer's and Parkinson's.
Cell & Microbiology
Sep 13, 2021
0
179
Co-aggregation of multiple pathogenic proteins is common in neurodegenerative diseases. However, the deconvolution of such biochemical process is still challenging.
Biochemistry
Jun 7, 2021
0
3
Scientists have discovered the first evidence of protein folding driven by liquid-liquid phase separation, a phenomenon in which fluids form into microscopic droplets and separate inside cells—like drops of oil in water.
Biochemistry
Feb 19, 2021
0
289
Cells require a balance among oxidation-reduction reactions, or redox homeostasis. Loss of that balance to create oxidative stress is often associated with neurodegeneration. Less is known about how loss of that balance at ...
Cell & Microbiology
Dec 9, 2020
0
2
A bacterium found among the soil close to roots of ginseng plants could provide a new approach for the treatment of Alzheimer's. Rhizolutin, a novel class of compounds with a tricyclic framework, significantly dissociates ...
Biochemistry
Nov 2, 2020
0
48
New simulations by Rice University scientists tell a tale of two taus and how they relate to neurological disease.
Biochemistry
Feb 3, 2020
0
127
Insights from their study may provide a novel therapeutic approach for diseases such as Huntington's and Parkinson's.
Molecular & Computational biology
Dec 7, 2019
1
902
Blood clots have long been implicated in heart attacks and strokes, together accounting for almost half of deaths annually in the United States. While the role of one key protein in the process, called von Willebrand factor, ...
General Physics
Nov 19, 2019
1
8
Hybrid plants—those produced by crossing two different types of parents—often die in conditions in which both parents would survive. It's called hybrid lethality. Certain hybrid tobacco plants, for example, thrive at ...
Biotechnology
Oct 10, 2019
0
10
