Protein kinase C
hideProtein kinase C also known as PKC (EC 2.7.11.13) is a family of enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol. Hence PKC enzymes play important roles in several signal transduction cascades.
The PKC family consists of ~10 isozymes. They are divided into three subfamilies, based on their second messenger requirements: conventional (or classical), novel, and atypical. Conventional (c)PKCs contain the isoforms α, βI, βII, and γ. These require Ca2+, diacylglycerol (DAG), and a phospholipid such as phosphatidylserine for activation. Novel (n)PKCs include the δ, ε, η, and θ isoforms, and require DAG, but do not require Ca2+ for activation. Thus, conventional and novel PKCs are activated through the same signal transduction pathway as phospholipase C. On the other hand, atypical (a)PKCs (including protein kinase Mζ and ι / λ isoforms) require neither Ca2+ nor diacylglycerol for activation. The term "protein kinase C" usually refers to the entire family of isoforms.
For more information about Protein kinase C, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
News tagged with protein kinase c
New findings bring hope for possible Parkinson's disease cure
Nov 03, 2009 |
5 / 5 (4) |
0
Researchers at Iowa State University have found an essential key to possibly cure Parkinson's disease and are looking for others.
Search results for protein kinase c
Cancers' sweet tooth may be weakness
Nov 18, 2009 |
5 / 5 (4) |
0
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
Pre-eclampsia linked to thyroid problems
Nov 18, 2009 |
not rated yet |
0
Women who develop pre-eclampsia during pregnancy are more likely than other women to have reduced thyroid function (hypothyroidism), finds a study published in BMJ today. It may also put women at a greater risk of thyroi ...
Study finds link between preeclampsia and reduced thyroid function
Nov 18, 2009 |
not rated yet |
0
Women who experience preeclampsia, a serious complication of pregnancy, may have an increased risk for reduced thyroid functioning later in life, report a team of researchers from the National Institutes of Health and other ...
Inhibition of GRK2 is protective against acute cardiac stress injuries
Nov 17, 2009 |
not rated yet |
0
Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion, according to two studies conducted at the Center for ...
An often overlooked protein actually a potent regulator of cardiac hypertrophy
Nov 16, 2009 |
4 / 5 (1) |
0
A protein long thought to be a secondary regulator in the heart's response to stressors like hypertension actually appears to be a primary regulator according to researchers from the Center for Translational Medicine at Thomas ...
Novel mouse gene reduces major pathologies associated with Alzheimer's disease
Medicine & Health / Neuroscience
Nov 11, 2009 |
3.8 / 5 (4) |
0
A new study reveals that a previously undiscovered mouse gene reduces the two major pathological perturbations commonly associated with Alzheimer's disease (AD). The research, published by Cell Press in the November 12 issue ...
Experimental agent reduces breast cancer metastasis to bone
Nov 03, 2009 |
5 / 5 (1) |
0
Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer. In a study in mice, the team of researchers ...
'Moonlighting' molecules discovered
Oct 29, 2009 |
5 / 5 (3) |
0
Since the completion of the human genome sequence, a question has baffled researchers studying gene control: How is it that humans, being far more complex than the lowly yeast, do not proportionally contain in our genome ...
Master regulator found for regenerating nerve fibers in live animals
Medicine & Health / Neuroscience
Oct 25, 2009 |
5 / 5 (11) |
0
Researchers at Children's Hospital Boston report that an enzyme known as Mst3b, previously identified in their lab, is essential for regenerating damaged axons (nerve fibers) in a live animal model, in both the peripheral ...
List of search results for protein kinase c
