News tagged with protein kinase
Diabetic kidney failure follows a 'ROCK'y road
A protein kinase known as ROCK1 can exacerbate an important process called fission in the mitochondria, the power plants of cells, leading to diabetic kidney disease, said researchers from Baylor College of Medicine in a ...
Feb 07, 2012 |
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Jak of all trades? Not of leukaemia therapy
About one in five or six cases of adult leukaemia in Western populations relates to so-called chronic myeloid leukaemia, or CML. Treatment of CML usually relies on inhibitors of the abnormal protein that causes the condition ...
Jan 30, 2012 |
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Selectively inhibiting PKM2 starves cancer cells
Crippling a protein that allows cancer cells to grow when oxygen is scarce causes tumors to regress, according to a study published online on January 23 in the Journal of Experimental Medicine.
Jan 23, 2012 |
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DGK-alpha helps cancer cells gain traction and mobilize
Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology reveals how a lipid-converting enzyme helps the cells mobilize these integrins.
Jan 23, 2012 |
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Three is the magic number: A chain reaction required to prevent tumor formation
Protein p53 is known for controlling the life and death of a cell and has a key role in cancer research. P53 is known to be inactive in 50 percent of cancer patients. If researchers succeed in re-establishing the presence ...
Jan 20, 2012 |
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Drugs used to overcome cancer may also combat antibiotic resistance: researchers
Drugs used to overcome cancer may also combat antibiotic resistance, finds a new study led by Gerry Wright, scientific director of the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University.
Dec 22, 2011 |
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Protein associated with learning implicated in causing grasshoppers to swarm
New research has found that a protein associated with learning and memory plays an integral role in changing the behaviour of locusts from that of harmless grasshoppers into swarming pests.
Dec 19, 2011 |
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Novel experimental agent is highly active in CLL patients, interim study shows
An interim analysis of a phase Ib/II clinical trial indicates that a novel experimental agent for chronic lymphocytic leukemia (CLL) is highly active and well tolerated in patients who have relapsed and are resistant to other ...
Dec 11, 2011 |
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Combination therapies for drug-resistant cancers
Some cancers can be effectively treated with drugs inhibiting proteins known as receptor tyrosine kinases, but not those cancers caused by mutations in the KRAS gene. A team of researchers led by Jeffrey Engelman, at Massachusetts ...
Oct 10, 2011 |
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Enzyme might be target for treating smoking, alcoholism at same time
An enzyme that appears to play a role in controlling the brain's response to nicotine and alcohol in mice might be a promising target for a drug that simultaneously would treat nicotine addiction and alcohol abuse in people, ...
Sep 12, 2011 |
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AMPK amplifies Huntington's disease
A new study describes how hyperactivation of AMP-activated protein kinase (AMPK) promotes neurodegeneration in Huntington's disease (HD). The article appears online on July 18, 2011, in The Journal of Cell Biology.
Jul 18, 2011 |
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In search of the memory molecule, a key protein complex discovered
Have a tough time remembering where you put your keys, learning a new language or recalling names at a cocktail party? New research from the Lisman Laboratory at Brandeis University points to a molecule that is central to ...
Medicine & Health / Neuroscience
Jun 23, 2011 |
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Cause and potential treatment found for cancer drug's kidney toxicity
Scientists may have a way to make the powerful cancer drug cisplatin less toxic to the kidneys and more effective against some cancers.
Jun 02, 2011 |
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The protein that makes us remember pain
(PhysOrg.com) -- New research by scientists in Arizona in the US has demonstrated that an enzyme makes the body remember and remain sensitive to pain after an injury has healed.
Medicine & Health / Neuroscience
May 13, 2011 |
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Team pinpoints role of key protein in pancreatic ductal adenocarcinoma
A team based at North Carolina Central University (NCCU) and UNC Lineberger Comprehensive Cancer Center has established a connection between a known cancer gene called KRAS and a protein called Pim-1 kinase.
May 11, 2011 |
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Protein kinase
A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction.
For more information about Protein kinase, read the full article at
Wikipedia.
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