Protein kinase
hideA protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction.
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News tagged with protein kinase
Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis
Nov 25, 2009 |
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Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers ...
New findings bring hope for possible Parkinson's disease cure
Nov 03, 2009 |
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Researchers at Iowa State University have found an essential key to possibly cure Parkinson's disease and are looking for others.
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Inhibition of GRK2 is protective against acute cardiac stress injuries
Nov 17, 2009 |
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Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion, according to two studies conducted at the Center for ...
Cancers' sweet tooth may be weakness
Nov 18, 2009 |
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The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
It takes two to infect: Structural biologists shed light on mechanism of invasion protein
Nov 30, 2009 |
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Bacteria are quite creative when infecting the human organism. They invade cells, migrate through the body, avoid an immune response and misuse processes of the host cell for their own purposes. To this end every bacterium ...
An often overlooked protein actually a potent regulator of cardiac hypertrophy
Nov 16, 2009 |
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A protein long thought to be a secondary regulator in the heart's response to stressors like hypertension actually appears to be a primary regulator according to researchers from the Center for Translational Medicine at Thomas ...
Novel mouse gene reduces major pathologies associated with Alzheimer's disease
Medicine & Health / Neuroscience
Nov 11, 2009 |
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A new study reveals that a previously undiscovered mouse gene reduces the two major pathological perturbations commonly associated with Alzheimer's disease (AD). The research, published by Cell Press in the November 12 issue ...
Pre-eclampsia linked to thyroid problems
Nov 18, 2009 |
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Women who develop pre-eclampsia during pregnancy are more likely than other women to have reduced thyroid function (hypothyroidism), finds a study published in BMJ today. It may also put women at a greater risk of thyroi ...
Experimental agent reduces breast cancer metastasis to bone
Nov 03, 2009 |
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Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer. In a study in mice, the team of researchers ...
Study finds link between preeclampsia and reduced thyroid function
Nov 18, 2009 |
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Women who experience preeclampsia, a serious complication of pregnancy, may have an increased risk for reduced thyroid functioning later in life, report a team of researchers from the National Institutes of Health and other ...
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