Protein kinase
hideA protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction.
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News tagged with protein kinase
Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis
Nov 25, 2009 |
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Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers ...
New findings bring hope for possible Parkinson's disease cure
Nov 03, 2009 |
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Researchers at Iowa State University have found an essential key to possibly cure Parkinson's disease and are looking for others.
Revealing cancers' weak spots: Researchers exploit genetic 'co-dependence' to kill treatment-resistant tumor cells
Oct 20, 2009 |
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(PhysOrg.com) -- Cancer cells fueled by the mutant KRAS oncogene, which makes them notoriously difficult to treat, can be killed by blocking a more vulnerable genetic partner of KRAS, report scientists at ...
Why one way of learning is better than another
Medicine & Health / Neuroscience
Oct 01, 2009 |
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A new study from the Montreal Neurological Institute and Hospital (The Neuro) of McGill University reveals that different patterns of training and learning lead to different types of memory formation. The significance of ...
Anti-cancer agent could be used to prevent premature birth
Oct 23, 2009 |
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(PhysOrg.com) -- Trichostatin A, an agent initially investigated in the laboratory as a possible cancer therapy, has been shown to inhibit contractions in muscle from the uterus and could have a role in preventing premature ...
Link uncovered between viral RNA and human immune response
Aug 04, 2009 |
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(PhysOrg.com) -- In its fight against an intruding virus, an enzyme in our immune system may sense certain types of viral RNA pairs, according to scientists.
Researchers discover, manipulate molecular interplay that moves cancer cells
Mar 29, 2009 |
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Based on research that reveals new insight into mechanisms that allow invasive tumor cells to move, researchers at the Mayo Clinic campus in Florida have a new understanding about how to stop cancer from spreading. A cancer ...
Tumor suppressor gene in flies may provide insights for human brain tumors
Jun 22, 2009 |
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In the fruit fly's developing brain, stem cells called neuroblasts normally divide to create one self-renewing neuroblast and one cell that has a different fate. But neuroblast growth can sometimes spin out of control and ...
How an enzyme tells stem cells which way to divide
May 14, 2009 |
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Driving Miranda, a protein in fruit flies crucial to switch a stem cell's fate, is not as complex as biologists thought, according to University of Oregon biochemists. They've found that one enzyme (aPKC) ...
New method for detection of phosphoproteins reveals regulator of melanoma invasion
Apr 09, 2009 |
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Scientists have developed a new approach for surveying phosphorylation, a process that is regulated by critical cell signaling pathways and regulates several key cellular signaling events. The research, published by Cell ...
New target identified for potential treatment of retinopathy in premature babies
May 04, 2009 |
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Results of a study in mice by researchers at the University of California, San Diego strongly suggest that the protein kinase JNK1 plays a key role in the development of retinopathy in premature infants. Their findings, ...
When it comes to sleep research, fruit flies and people make unlikely bedfellows
Biology /
Jan 13, 2009 |
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You may never hear fruit flies snore, but rest assured that when you're asleep they are too. According to research published in the January 2009 issue of the journal Genetics, scientists from the University of Missouri-Kansas City h ...
Research shows safe dosages of common pain reliever may help prevent conditions related to aging
Sep 23, 2009 |
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Recent studies conducted by Dr. Eric Blough and his colleagues at Marshall University have shown that use of the common pain reliever acetaminophen may help prevent age-associated muscle loss and other conditions.
Protein that promotes cancer cell growth identified
Jul 24, 2009 |
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Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer ...
Protein can help cells or cause cancer, researcher finds
Jul 07, 2009 |
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A Purdue University scientist has discovered a key process in cell growth that can lead to the formation of tumors.
