Protein kinase
hideA protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction.
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News tagged with protein kinase
New findings bring hope for possible Parkinson's disease cure
Nov 03, 2009 |
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Researchers at Iowa State University have found an essential key to possibly cure Parkinson's disease and are looking for others.
How an enzyme tells stem cells which way to divide
May 14, 2009 |
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Driving Miranda, a protein in fruit flies crucial to switch a stem cell's fate, is not as complex as biologists thought, according to University of Oregon biochemists. They've found that one enzyme (aPKC) ...
Research shows safe dosages of common pain reliever may help prevent conditions related to aging
Sep 23, 2009 |
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Recent studies conducted by Dr. Eric Blough and his colleagues at Marshall University have shown that use of the common pain reliever acetaminophen may help prevent age-associated muscle loss and other conditions.
Why one way of learning is better than another
Medicine & Health / Neuroscience
Oct 01, 2009 |
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A new study from the Montreal Neurological Institute and Hospital (The Neuro) of McGill University reveals that different patterns of training and learning lead to different types of memory formation. The significance of ...
Researchers discover, manipulate molecular interplay that moves cancer cells
Mar 29, 2009 |
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Based on research that reveals new insight into mechanisms that allow invasive tumor cells to move, researchers at the Mayo Clinic campus in Florida have a new understanding about how to stop cancer from spreading. A cancer ...
New method for detection of phosphoproteins reveals regulator of melanoma invasion
Apr 09, 2009 |
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Scientists have developed a new approach for surveying phosphorylation, a process that is regulated by critical cell signaling pathways and regulates several key cellular signaling events. The research, published by Cell ...
Anti-cancer agent could be used to prevent premature birth
Oct 23, 2009 |
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(PhysOrg.com) -- Trichostatin A, an agent initially investigated in the laboratory as a possible cancer therapy, has been shown to inhibit contractions in muscle from the uterus and could have a role in preventing premature ...
Revealing cancers' weak spots: Researchers exploit genetic 'co-dependence' to kill treatment-resistant tumor cells
Oct 20, 2009 |
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(PhysOrg.com) -- Cancer cells fueled by the mutant KRAS oncogene, which makes them notoriously difficult to treat, can be killed by blocking a more vulnerable genetic partner of KRAS, report scientists at ...
Link uncovered between viral RNA and human immune response
Aug 04, 2009 |
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(PhysOrg.com) -- In its fight against an intruding virus, an enzyme in our immune system may sense certain types of viral RNA pairs, according to scientists.
Tumor suppressor gene in flies may provide insights for human brain tumors
Jun 22, 2009 |
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In the fruit fly's developing brain, stem cells called neuroblasts normally divide to create one self-renewing neuroblast and one cell that has a different fate. But neuroblast growth can sometimes spin out of control and ...
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
Feb 24, 2009 |
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Scientists have determined that a specific gene plays a role in the weight-gain response to a high-fat diet. The finding in an animal study suggests that blocking this gene could one day be a therapeutic strategy to reduce ...
2-drug combination appears safe and active in metastatic kidney cancer
May 31, 2009 |
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Fox Chase Cancer Center investigators report that a two-drug blockade of mTOR signaling appears safe in metastatic kidney cancer in a phase I trial. Early data suggests that a combination of temsirolimus and bryostatin may ...
