News tagged with protein p53
DGK-alpha helps cancer cells gain traction and mobilize
Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology reveals how a lipid-converting enzyme helps the cells mobilize these integrins.
Jan 23, 2012 |
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Three is the magic number: A chain reaction required to prevent tumor formation
Protein p53 is known for controlling the life and death of a cell and has a key role in cancer research. P53 is known to be inactive in 50 percent of cancer patients. If researchers succeed in re-establishing the presence ...
Jan 20, 2012 |
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Explaining heart failure as a cause of diabetes
Either heart failure or diabetes alone is bad enough, but oftentimes the two conditions seem to go together. Now, researchers reporting in the January Cell Metabolism appear to have found the culprit that leads from heart ...
Jan 03, 2012 |
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HPV linked to cardiovascular disease in women
Women with cancer-causing strains of human papillomavirus (HPV) may be at increased risk for cardiovascular disease (CVD) and stroke even when no conventional risk factors for CVD are present.
Medicine & Health / Cardiology
Oct 24, 2011 |
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Researchers identify potential molecular target to prevent growth of cancer cells
Researchers have shown for the first time that the protein fortilin promotes growth of cancer cells by binding to and rendering inert protein p53, a known tumor suppressor. This finding by researchers at the University of ...
Sep 16, 2011 |
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A chaperone for the 'guardian of the genome'
The protein p53 plays an essential role in the prevention of cancer by initiating the controlled death of a cell with damaged genes which is in danger to transform into a cancerous cell. The heat shock protein Hsp90, in turn, ...
Sep 07, 2011 |
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Gene found to play role in early cancer
(Medical Xpress) -- Mutations to a gene called p53 have been linked to half of all cancers, leading to tumor growth and the spread of cancerous cells. Now, a Cornell-led study identifies for the first time the mechanisms ...
Aug 24, 2011 |
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At last, a reason why stress causes DNA damage
For years, researchers have published papers that associate chronic stress with chromosomal damage.
Aug 21, 2011 |
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The genome guardian's dimmer switch: Regulating p53 is a matter of life or death
Scientists at the Salk Institute for Biological Studies have found clues to the functioning of an important damage response protein in cells. The protein, p53, can cause cells to stop dividing or even to commit suicide when ...
Jun 30, 2011 |
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New discoveries about tumor-suppressing protein could help to reduce treatment side effects
Researchers at the Stanford University School of Medicine have untangled two distinct ways in which a common, naturally occurring "tumor-suppressor" protein works. The separation of these two functions — which can have ...
May 12, 2011 |
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Computer modeling used to study protein involved with cancer, aging and chronic disease
(PhysOrg.com) -- A new biophysical and biochemical study may lead to better understanding of how structural flexibility controls the interaction of a protein that is closely involved with cancer, aging and other chronic diseases ...
Apr 13, 2011 |
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Cancer is a p53 protein aggregation disease
Protein aggregation, generally associated with Alzheimer's and mad cow disease, turns out to play a significant role in cancer. In a paper published in Nature Chemical Biology, Frederic Rousseau and Joost Schymkowitz of VIB ...
Mar 29, 2011 |
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Protein and microRNA block cellular transition vital to metastasis
Like a bounty hunter returning escapees to custody, a cancer-fighting gene converts organ cells that change into highly mobile stem cells back to their original, stationary state, researchers report online at Nature Cell Bi ...
Feb 25, 2011 |
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Why chemotherapy causes more infertility in women than in men
For a long time a relationship between infertility and chemotherapeutic agents has been assumed. Now, the mechanism has been elucidated. Mainly women are affected because the quality control in the oocytes is different from ...
Feb 22, 2011 |
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Eggs' quality control mechanism explained
To protect the health of future generations, body keeps a careful watch on its precious and limited supply of eggs. That's done through a key quality control process in oocytes (the immature eggs), which ensures elimination ...
Feb 17, 2011 |
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