Protein structure
hideProteins are an important class of biological macromolecules present in all biological organisms, made up of such elements as carbon, hydrogen, nitrogen, oxygen, and sulphur. All proteins are polymers of amino acids. The polymers, also known as polypeptides, consist of a sequence of 20 different L-α-amino acids, also referred to as residues. For chains under 40 residues the term peptide is frequently used instead of protein. To be able to perform their biological function, proteins fold into one, or more, specific spatial conformations, driven by a number of noncovalent interactions such as hydrogen bonding, ionic interactions, Van Der Waals forces and hydrophobic packing. In order to understand the functions of proteins at a molecular level, it is often necessary to determine the three dimensional structure of proteins. This is the topic of the scientific field of structural biology, that employs techniques such as X-ray crystallography or NMR spectroscopy, to determine the structure of proteins.
A number of residues are necessary to perform a particular biochemical function, and around 40-50 residues appears to be the lower limit for a functional domain size. Protein sizes range from this lower limit to several thousand residues in multi-functional or structural proteins. However, the current estimate for the average protein length is around 300 residues. Very large aggregates can be formed from protein subunits, for example many thousand actin molecules assemble into a microfilament.
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News tagged with protein structure
Green tea chemical combined with another may hold promise for treatment of brain disorders
Dec 03, 2009 |
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Scientists at Boston Biomedical Research Institute (BBRI) and the University of Pennsylvania have found that combining two chemicals, one of which is the green tea component EGCG, can prevent and destroy a variety of protein ...
The hidden lives of proteins
Dec 02, 2009 |
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An important Brandeis study appearing in the December 3 issue of Nature raises the curtain on the hidden lives of proteins at the atomic level. The study reports that for the first time, researchers used x ...
Scientists reveal key structure from ebola virus
Dec 08, 2009 |
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Scientists at The Scripps Research Institute have determined the structure of a critical protein from the Ebola virus, which, though rare, is one of the deadliest viruses on the planet killing between 50 and 90 percent of ...
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BBS proteins shown to run an export business that protects cilia
Dec 28, 2009 |
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A protein complex mutated in human disease removes excess signaling molecules to prevent them from damaging cilia, say researchers from UMass Medical School. The study will be published in the December 28 ...
Emerald BioStructures announces discovery of small molecule modulators of PDE4
Dec 27, 2009 |
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Emerald BioStructures (formerly deCODE biostructures) announced a publication in the December 27, 2009 advance online issue of Nature Biotechnology, detailing the application of structure-based drug design (SBDD) to engine ...
Research yields new agent for some drug-resistant non-small cell lung cancers
Dec 23, 2009 |
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The ability to make, test, and map the atomic structure of new anti-cancer agents has enabled a team of Dana-Farber Cancer Institute scientists to discover a compound capable of halting a common type of drug-resistant ...
Novel nanotechnology heals abscesses caused by resistant staph bacteria
Nanotechnology / Bio & Medicine
Dec 22, 2009 |
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Researchers at the Albert Einstein College of Medicine of Yeshiva University have developed a new approach for treating and healing skin abscesses caused by bacteria resistant to most antibiotics. The study ...
Nanoscale changes in collagen are a tipoff to bone health
Dec 22, 2009 |
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Using a technique that provides detailed images of nanoscale structures, researchers at the University of Michigan and Detroit's Henry Ford Hospital have discovered changes in the collagen component of bone ...
New insight in nerve cell communication
Medicine & Health / Neuroscience
Dec 22, 2009 |
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Communication between nerve cells is vital for our bodies to function. Part of this communication happens through vesicles containing signalling molecules called neurotransmitters. The vesicle fuses with the ...
Gene for devastating kidney disease discovered
Dec 22, 2009 |
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(PhysOrg.com) -- Researchers from Children's Hospital Boston and Brigham and Women's Hospital have identified an important genetic cause of a devastating kidney disease that is the second leading cause of kidney failure in ...
Researchers are on the path to creating nano-MRI images
Dec 22, 2009 |
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(PhysOrg.com) -- Cornell researchers are devising methods to detect the magnetic fields of individual electrons and atomic nuclei, which they hope to use to make a nanoscale version of magnetic resonance imaging.
Proline Repeats in Protein Help Grow Tooth Enamel (w/ Podcast)
Dec 21, 2009 |
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(PhysOrg.com) -- A simple amino acid that is repeated in the center of proteins found in tooth enamel makes teeth stronger and more resilient, according to new research at the University of Illinois at Chicago.
Making New Enzymes to Engineer Plants for Biofuel Production
Dec 21, 2009 |
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(PhysOrg.com) -- Brookhaven scientists have created a new enzyme with the potential to interfere with a key cell-wall component in plants, possibly leading to plants that are easier to "digest" and convert ...
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