News tagged with pyruvate
Study reveals details of alternative splicing circuitry that promotes cancer's Warburg effect
Cancer cells maintain their life-style of extremely rapid growth and proliferation thanks to an enzyme called PK-M2 (pyruvate kinase M2) that alters the cells' ability to metabolize glucose – a phenomenon known as the ...
Nov 02, 2011 |
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Metabolic shift may offer early cancer clue
Cancer cells are well known for their altered metabolisms, which may help them generate the energy they need for rapid growth. Using an emerging imaging technology, researchers reporting in the July Cell Metabolism, a Cell ...
Jul 05, 2011 |
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To starve a tumor
(PhysOrg.com) -- Since the 1920s, scientists have known that cancer cells generate energy differently than normal cells, a phenomenon dubbed the 'Warburg effect' after its discoverer, German biochemist Otto ...
Apr 06, 2010 |
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Transporter could help breast cancer cells commit suicide
Researchers are trying to open a door for a killer that breast cancer cells shut out.
Feb 17, 2009 |
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Search results for pyruvate
Rituximab possible treatment option for patients with primary biliary cirrhosis
An open-label study of rituximab, a monoclonal antibody for human CD20, was shown to be safe in patients with primary biliary cirrhosis (PBC) who had an incomplete response to the standard ursodeoxycholic acid (UDCA) therapy, ...
Feb 02, 2012 |
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Selectively inhibiting PKM2 starves cancer cells
Crippling a protein that allows cancer cells to grow when oxygen is scarce causes tumors to regress, according to a study published online on January 23 in the Journal of Experimental Medicine.
Jan 23, 2012 |
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Enzyme that flips switch on cells' sugar cravings could be anti-cancer target
Cancer cells tend to take up more glucose than healthy cells, and researchers are increasingly interested in exploiting this tendency with drugs that target cancer cells' altered metabolism.
Dec 22, 2011 |
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High levels of tau protein linked to poor recovery after brain injury
High levels of tau protein in fluid bathing the brain are linked to poor recovery after head trauma, according to a study from Washington University School of Medicine in St. Louis and the Fondazione IRCCS ...
Medicine & Health / Neuroscience
Dec 13, 2011 |
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Metabolic protein plays unexpected role in tumor cell formation and growth
The embryonic enzyme pyruvate kinase M2 (PKM2) has a well-established role in metabolism and is highly expressed in human cancers. Now, a team led by researchers at the University of Texas MD Anderson Cancer Center reports ...
Nov 06, 2011 |
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Study identifies an expanded role for PKM2 in helping cancer cells survive
It has long been known that cancer cells use nutrients differently than normal cells. In recent years, the rapidly reemerging field of cancer metabolism has shed new light on the ways that cancers use glucose to grow and ...
Nov 03, 2011 |
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Cellular metabolism self-adapts to protect against free radicals
Oxygen-consuming organisms obtain energy through cellular respiration, which is the transformation of carbohydrates and oxygen into carbon dioxide and water. This process also produces toxic oxygen radicals which must be ...
Sep 07, 2011 |
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Mechanism of action behind novel cancer agents targeting tumor cell metabolism discovered
(Medical Xpress) -- The discovery of the mechanism of action behind a novel class of anticancer drugs designed to disrupt cancer cell mitochondrial metabolism may be a major step toward furthering clinical trials of the agents. ...
Jul 26, 2011 |
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Massive enzyme footballs control sugar metabolism
Neutrons have shown how massive enzyme complexes inside cells might determine whether sugar is burnt for energy or stored as fat. These findings will improve understanding of diabetes and a range of metabolic ...
Jul 20, 2011 |
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As new data wave begins, a gene study in one disease discovers mutations in an unrelated disease
Often enough, in science as in life, unexpected knowledge has a personal impact. Researchers seeking rare gene variants in just a few individuals with attention-deficit hyperactivity disorder (ADHD) discovered that one patient ...
Jul 20, 2011 |
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List of search results for pyruvate
