Related topics: dna repair

'Soft' CRISPR may offer a new fix for genetic defects

Curing debilitating genetic diseases is one of the great challenges of modern medicine. During the past decade, development of CRISPR technologies and advancements in genetics research brought new hope for patients and their ...

Developing tools to visualize DNA repair as never before

Each one of the trillions of cells that make up the human body suffers more than 10,000 DNA lesions every day. These injuries would be catastrophic if cells were unable to repair them, but a very delicate machinery that detects ...

Solving a long-standing biological search problem

How the cell can mend broken DNA using another DNA copy as template has puzzled researchers for years. How is it possible to find the correct sequences in the busy interior of the cell? Researchers from Uppsala university ...

A new mechanism for accessing damaged DNA

UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by DNA repair machinery, acting as a molecular sunscreen. It has been unclear, however, how repair proteins work on DNA ...

The state of CRISPR research

CRISPR has been hailed as one of the most promising gene editing technologies and promises to revolutionize precision medicine and eradicate genetic diseases. However, the technique is not perfect and needs improvements. ...

Scientists identify protein profiles of DNA repair

During each cell division, more than 3.3 billion base pairs of genomic DNA have to be duplicated and segregated accurately to daughter cells. But what happens when the DNA template is damaged in such a way that the replication ...

A question of gene silencing

When investigating cancer cells, researchers discovered numerous peculiarities: Particular RNA molecules are present in large numbers, particular genes are overactive. Do these characteristics have a relation to cancer? Do ...

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