The DNA molecules in our cells can be damaged by various extrinsic and intrinsic factors called genotoxic stressors; persistent and unchecked damage can lead to developing diseases like cancer. Fortunately, our cells don't ...
Cell & Microbiology
Apr 26, 2023
0
8
Today in Nature, University of Pittsburgh researchers describe for the first time a pathway by which cells repair damaged lysosomes, structures that contribute to longevity by recycling cellular trash. The findings are an ...
Cell & Microbiology
Sep 7, 2022
0
18
A new editorial paper titled "WRNing for the right DNA repair pathway choice" has been published in Aging .
Molecular & Computational biology
Jun 16, 2022
0
7
Since the discovery of CRISPR/Cas9, also known as molecular scissors, scientists around the world have been working to improve the revolutionary technique for altering DNA that earned Emmanuelle Charpentier and Jennifer Doudna ...
Molecular & Computational biology
Feb 9, 2022
0
72
From cancer treatment to sunlight, radiation and toxins can severely damage DNA in both harmful and healthy cells. While the body has evolved to efficiently treat and restore damaged cells, the mechanisms that allow this ...
Molecular & Computational biology
Apr 15, 2021
0
150
A new bioluminescent reporter that tracks DNA double stranded break (DSB) repair in cells has been developed by researchers from Massachusetts General Hospital (MGH) and the Academia Sinica in Taiwan. The international team's ...
Biotechnology
Aug 21, 2020
0
202
Homologous recombination is an essential process of DNA repair to maintain genomic integrity of the organism. Now, researchers from Japan have identified mechanisms that choose between alternate pathways of DNA repair to ...
Evolution
Apr 30, 2020
0
17
Scientists have discovered a way to manipulate the body's own immune response to boost tissue repair. The findings, published in Current Biology today, reveal a new network of protective factors to shield cells against damage. ...
Biochemistry
Nov 18, 2019
1
855
By analyzing how metabolic enzymes are built and organized, researchers have reconstructed the evolutionary history of metabolism. Their study shows how metabolic networks—which drive every cellular process from protein ...
Cell & Microbiology
Oct 28, 2019
0
23
Scientists at UMass Medical School have developed a strategy for editing and repairing a particular type of genetic mutation associated with microduplications using CRISPR-Cas9 and a seldom-used DNA repair pathway. Described ...
Biotechnology
Apr 4, 2019
0
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