News tagged with rett syndrome
Discovery may lead to new treatment for Rett Syndrome
Researchers at Oregon Health & Science University have discovered that a molecule critical to the development and plasticity of nerve cells – brain-derived neurotrophic factor (BDNF) -- is severely lacking in brainstem ...
Medicine & Health / Neuroscience
Jan 28, 2012 |
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Study finds two genes affect anxiety, behavior in mice with too much MeCP2
The anxiety and behavioral issues associated with excess MeCP2 protein result from overexpression of two genes (Crh [corticotropin-releasing hormone] and Oprm 1 [mu-opioid receptor MOR 1]), which may point the way to treating ...
Jan 08, 2012 |
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A role for glia in the progression of Rett syndrome
A paper published online today in Nature reveals that glia play a key role in preventing the progression of the most prominent Rett Syndrome symptoms displayed by mouse models of the disease: lethality, irregular breathing and ap ...
Jun 29, 2011 |
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Clinical trial for Rett syndrome launched
Researchers at Children's Hospital Boston have begun a randomized, placebo-controlled trial to test a potential drug treatment for Rett syndrome, the leading known genetic cause of autism in girls. The drug, mecasermin, a ...
Dec 16, 2010 |
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Rett syndrome mobilizes jumping genes in the brain
With few exceptions, jumping genes-restless bits of DNA that can move freely about the genome-are forced to stay put. In patients with Rett syndrome, however, a mutation in the MeCP2 gene mobilizes so-called ...
Nov 17, 2010 |
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Researchers 'grow Rett syndrome' in a Petri dish
A groundbreaking study published Friday in the leading scientific journal, Cell, revealed that a team of investigators had successfully generated nerve cells using skin cells from four individuals with Rett syndrome. The st ...
Nov 15, 2010 |
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Inhibitory neurons key to understanding neuropsychiatric disorders
The brain works because 100 billion of its special nerve cells called neurons regulate trillions of connections that carry and process information. The behavior of each neuron is precisely determined by the proper function ...
Nov 10, 2010 |
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Life threatening breathing disorder of Rett syndrome prevented
A group of researchers at the University of Bristol have sequestered the potentially fatal breath holding episodes associated with the autistic-spectrum disorder Rett syndrome.
Oct 04, 2010 |
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MeCP2 goes global -- redefining the function of the Rett syndrome protein
A paper published online today in Molecular Cell proposes that Methyl CpG binding protein 2 (MeCP2) impacts the entire genome in neurons, rather than acting as a regulator of specific genes. Mutations in MeCP2 cause the au ...
Feb 25, 2010 |
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A common thread links multiple human cognitive disorders
A new study reveals that a common underlying mechanism is shared by a group of previously unrelated disorders which all cause complex defects in brain development and function. Rett syndrome (RTT), Cornelia de Lange syndrome ...
Feb 15, 2010 |
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New insight into Rett syndrome severity
A research collaboration between Australia and Israel has identified a genetic variation that influences the severity of symptoms in Rett syndrome.
Medicine & Health / Neuroscience
Apr 20, 2009 |
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Rett Syndrome scientist makes significant discovery
A paper published online today in Nature Neuroscience reveals the presence of methyl CpG binding protein 2 (MeCP2) in glia. MeCP2 is a protein associated with a variety of neurological disorders, including Rett Syndrome, the mo ...
Feb 23, 2009 |
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Study suggests possible treatment for neurological disorder Rett syndrome
Using injections of a small derivate of the protein insulin-like growth factor-1 (IGF-1), scientists at Whitehead Institute for Biomedical Research and MIT's Picower Institute for Learning and Memory have successfully treated ...
Feb 09, 2009 |
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