News tagged with rna splicing
Researchers find mutation causing neurodegeneration
A Jackson Laboratory research team led by Professor and Howard Hughes Medical Investigator Susan Ackerman, Ph.D., has discovered a defect in the RNA splicing process in neurons that may contribute to neurological disease.
Jan 19, 2012 |
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Massive DNA search uncovers new mutations driving blood cancer
The most comprehensive search to date of DNA abnormalities in chronic lymphocytic leukemia (CLL) has unearthed several new altered genes that drive this common blood cancer, a finding that could potentially ...
Dec 12, 2011 |
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Genetic screening in yeast reveals new candidate gene for Lou Gehrig's disease
(Medical Xpress) -- Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a universally fatal neurodegenerative disease. Mutations in two related proteins, TDP-43 and FUS, cause some forms of ALS. ...
Nov 15, 2011 |
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Temperature controls the genetic message
Alternative splicing, the mechanism enabling a gen to encode different proteins, according to the cell's needs, still holds many secrets. It has transformed the initial theory of one gen, one protein, but how it is controlled ...
Sep 16, 2011 |
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New link found between obesity and insulin resistance
Obesity is the main culprit in the worldwide avalanche of type 2 diabetes. But how excess weight drives insulin resistance, the condition that may lead to the disease, is only partly understood. Scientists at Joslin Diabetes ...
Aug 02, 2011 |
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New mechanism in the regulation of human genes
Scientists at the Technical University of Munich and the Helmholtz Zentrum Muenchen and along with their colleagues from the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Centre for Genomic Regulation ...
Jul 14, 2011 |
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New information revealed about a protein implicated in autism and similar disorders; could lead to better drug design
(Medical Xpress) -- University of Michigan researcher Gabrielle Rudenko and her Life Sciences Institute lab have solved the structure of a protein that is implicated in a number of neuropsychiatric disorders including autism ...
Jul 08, 2011 |
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Genetic mutation linked to lethal disease
Researchers have identified a genetic mutation found in the Ohio Amish population as the cause of a fatal developmental disease in fetuses and infants, according to research published in the April 8, 2011, issue of Science.
Apr 18, 2011 |
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Lasers, custom microscope show gene splicing process in real time
From neurosurgery to bar code readers, lasers have been used in a myriad of applications since they were first introduced in the late 1950's. Now, with the work being done in Jeff Gelles' Lab at Brandeis University, ...
Mar 10, 2011 |
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Engineered molecule changes itself to detect and attack diseased cells
(PhysOrg.com) -- Assistant Professor of Bioengineering Christina Smolke has engineered biological molecules that regulate a cell's behavior by adjusting their own forms and functions in response to the internal conditions ...
Nov 30, 2010 |
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Cancer-associated long non-coding RNA regulates pre-mRNA splicing
Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production. Their study appears in the ...
Sep 23, 2010 |
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Spying on a cellular director in the cutting room
Like a film director cutting out extraneous footage to create a blockbuster, the cellular machine called the spliceosome snips out unwanted stretches of genetic material and joins the remaining pieces to fashion a template ...
Mar 21, 2010 |
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Gladstone scientists identify role of key protein in ALS and frontotemporal dementia
Scientists at the Gladstone Institute of Neurological Disease (GIND) have identified the reason a key protein plays a major role in two neurodegenerative diseases. In the current edition of the Journal of Neuroscience, re ...
Medicine & Health / Neuroscience
Jan 12, 2010 |
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Possible help in fight against muscle-wasting disease (w/ Video)
(PhysOrg.com) -- A compound already used to treat pneumonia could become a new therapy for an inherited muscular wasting disease, according to researchers at the University of Oregon and the University of ...
Nov 06, 2009 |
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Researchers identify drug candidate for treating spinal muscular atrophy
A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants. This is the finding of ...
Nov 04, 2009 |
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