Schizophrenia
hideSchizophrenia (SCZ) (pronounced /ˌskɪtsɵˈfrɛniə/ or /ˌskɪtsɵˈfriːniə/), from the Greek roots skhizein (σχίζειν, "to split") and phrēn, phren- (φρήν, φρεν-; "mind") is a psychiatric diagnosis that describes a mental disorder characterized by abnormalities in the perception or expression of reality. Distortions in perception may affect all five senses, including sight, hearing, taste, smell and touch, but most commonly manifest as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking with significant social or occupational dysfunction. Onset of symptoms typically occurs in young adulthood, with approximately 0.4–0.6% of the population affected. Diagnosis is based on the patient's self-reported experiences and observed behavior. No laboratory test for schizophrenia currently exists.
Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Current psychiatric research is focused on the role of neurobiology, but no single organic cause has been found. Due to the many possible combinations of symptoms, there is debate about whether the diagnosis represents a single disorder or a number of discrete syndromes. For this reason, Eugen Bleuler termed the disease the schizophrenias (plural) when he coined the name. Despite its etymology, schizophrenia is not the same as dissociative identity disorder, previously known as multiple personality disorder or split personality, with which it has been erroneously confused.
Increased dopamine activity in the mesolimbic pathway of the brain is consistently found in schizophrenic individuals. The mainstay of treatment is antipsychotic medication; this type of drug primarily works by suppressing dopamine activity. Dosages of antipsychotics are generally lower than in the early decades of their use. Psychotherapy, and vocational and social rehabilitation are also important. In more serious cases—where there is risk to self and others—involuntary hospitalization may be necessary, although hospital stays are less frequent and for shorter periods than they were in previous times.
The disorder is thought to mainly affect cognition, but it also usually contributes to chronic problems with behavior and emotion. People with schizophrenia are likely to have additional (comorbid) conditions, including major depression and anxiety disorders; the lifetime occurrence of substance abuse is around 40%. Social problems, such as long-term unemployment, poverty and homelessness, are common. Furthermore, the average life expectancy of people with the disorder is 10 to 12 years less than those without, due to increased physical health problems and a higher suicide rate.
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News tagged with schizophrenia
Schizophrenia gene's role may be broader, more potent, than thought
Nov 19, 2009 |
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(PhysOrg.com) -- UCSF scientists studying nerve cells in fruit flies have uncovered a new function for a gene whose human equivalent may play a critical role in schizophrenia.
Using Brain Waves to Help Treat Depression
Sep 22, 2009 |
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(PhysOrg.com) -- Researchers conducted a study at 9 sites in the U.S. with 375 people suffering from major depression. The testing takes about 15 minutes and could help people suffering from depression find ...
Rats' mental 'instant replay' drives next moves
Medicine & Health / Neuroscience
Aug 26, 2009 |
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(PhysOrg.com) -- Researchers at MIT’s Picower Institute for Learning and Memory have found that rats use a mental instant replay of their actions to help them decide what to do next, shedding new light on how ...
Study shows that a combination of common genetic variations can lead to schizophrenia
Jul 01, 2009 |
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A multi-national group of investigators, including a scientist at the University of North Carolina at Chapel Hill, has discovered that nearly a third of the genetic basis of schizophrenia may be attributed ...
Flow of potassium into cells implicated in schizophrenia
May 06, 2009 |
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A study on schizophrenia has implicated machinery that maintains the flow of potassium in cells and revealed a potential molecular target for new treatments. Expression of a previously unknown form of a key ...
Research supports toxoplasmosis link to schizophrenia
Mar 11, 2009 |
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Scientists have discovered how the toxoplasmosis parasite may trigger the development of schizophrenia and other bipolar disorders.
Human brains pay a price for being big
Biology /
Aug 05, 2008 |
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Metabolic changes responsible for the evolution of our unique cognitive abilities indicate that the brain may have been pushed to the limit of its capabilities. Research published today in BioMed Central's open access journal ...
Research backs theory on autism, schizophrenia
Nov 30, 2009 |
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(PhysOrg.com) -- New research by Simon Fraser University evolutionary biologist Bernard Crespi reinforces his theory that autism and schizophrenia are diametric or opposite conditions based on genes.
New 'schizophrenia gene' prompts researchers to test potential drug target
Medicine & Health / Neuroscience
Oct 27, 2009 |
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Johns Hopkins scientists report having used a commercially available drug to successfully "rescue" animal brain cells that they had intentionally damaged by manipulating a newly discovered gene that links susceptibility genes ...
Faulty 'wiring' in the brain triggers onset of schizophrenia
Medicine & Health / Psychology & Psychiatry
Oct 26, 2009 |
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A new study by researchers at the Institute of Psychiatry (IoP), King's College London has discovered abnormalities in the white matter of the brain that seem to be critical for the timing of schizophrenia. The study, led ...
Rare mutation dramatically increasing schizophrenia risk
Oct 25, 2009 |
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An international team of researchers led by geneticist Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL), has identified a mutation on human chromosome 16 that substantially increases risk for schizophrenia.
Scientists demonstrate link between genetic defect and brain changes in schizophrenia
Medicine & Health / Psychology & Psychiatry
Oct 16, 2009 |
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For decades, scientists have thought the faulty neural wiring that predisposes individuals to behavioral disorders like autism and psychiatric diseases like schizophrenia must occur during development. Even so, no one has ...
Getting wired: How the brain does it
Medicine & Health / Neuroscience
Aug 26, 2009 |
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In a new study, researchers at the Montreal Neurological Institute and Hospital (The Neuro), McGill University have found an important mechanism involved in setting up the vast communications network of connections ...
Scientists try to stop schizophrenia in its tracks
Jul 26, 2009 |
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(AP) -- She was sociable and happy in high school. But in college that changed abruptly: Depressed and withdrawn, some days she couldn't get out of bed. And that wasn't all.
Alterations in brain's white matter key to schizophrenia, study shows
Medicine & Health / Psychology & Psychiatry
Jun 22, 2009 |
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Schizophrenia, a chronic and debilitating disorder marked in part by auditory hallucinations and paranoia, can strike in late adolescence or early adulthood at a time when people are ready to stand on their own two feet as ...
