News tagged with senescent cells
Cell senescence does not stop tumor growth
Since cancer cells grow indefinitely, it is commonly believed that senescence could act as a barrier against tumor growth and potentially be used as a way to treat cancer. A collaboration between a cancer biologist from the ...
Jan 19, 2012 |
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Medical researchers decoding the aging process
Scientists are beginning to decode the complex biology of aging and are optimistic that recent advances in research may lead to treatments that can slow or even reverse degeneration and disease.
Nov 15, 2011 |
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The body's own surveillance system against cancer
(Medical Xpress) -- Liver cell carcinoma is one of the most abundant malign cancer diseases worldwide. In the majority of cases its emergence is triggered by cirrhosis of the liver which is caused by chronic ...
Nov 09, 2011 |
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Researchers discover tactic to delay age-related disorders
Researchers at Mayo Clinic have shown that eliminating cells that accumulate with age could prevent or delay the onset of age-related disorders and disabilities. The study, performed in mouse models, provides the first evidence ...
Nov 02, 2011 |
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Genetics of melanoma chemoresistance
Malignant melanoma is a highly aggressive and notoriously chemoresistant form of cancer. In a new paper, Ohanna et al. reveal that anti-melanoma drugs may, paradoxically, induce a senescence-associated secretory profile ("secretome") ...
Jun 06, 2011 |
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Aging, obsolete cells prime the lungs for pneumonia
Community-acquired pneumonia is the leading cause of infectious death among the elderly. Newly published research from The University of Texas Health Science Center San Antonio suggests why older people are ...
May 26, 2011 |
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Cell division abnormality contributes to inflammation in COPD
Changes in the ability of lung cells to divide may play a role in initiating or prolonging lung tissue inflammation, a hallmark of chronic obstructive pulmonary disease (COPD), according to a study conducted by researchers ...
May 15, 2011 |
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Scientists now know why some cancers become malignant and others don't
Cancer cells reproduce by dividing in two, but a molecule known as PML limits how many times this can happen, according to researchers lead by Dr. Gerardo Ferbeyre of the University of Montreal's Department of Biochemistry. ...
Jan 06, 2011 |
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Control of cancer cell pathways key to halting disease spread, study shows
Oncogenes are like friends who've gone off the deep end. Normally steady, reliable members of the cellular workforce, these genes become very bad influences when mutated or expressed at high levels -- urging a cell to divide ...
Jun 14, 2010 |
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Researchers discover mechanism that limits scar formation
Researchers from the University of Illinois at Chicago have discovered that an unexpected cellular response plays an important role in breaking down and inhibiting the formation of excess scar tissue in wound healing.
Jun 10, 2010 |
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Scientists discover how a tumor suppressor induces senescence and staves off cancer
A frequently mutated gene in human cancers is the reitnoblastoma (RB) gene, which controls a potent tumor suppression pathway. Mutations in the gene disable the vast and intricate RB pathway in virtually all tumor cells, ...
Apr 13, 2010 |
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Disabling Skp2 gene helps shut down cancer growth
Increased understanding of the Skp2 gene and its relation to cellular senescence may lead to the development of novel agents that can suppress tumor development in common types of cancer, researchers from The University of ...
Mar 17, 2010 |
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Longevity tied to genes that preserve tips of chromosomes
A team led by researchers at Albert Einstein College of Medicine of Yeshiva University has found a clear link between living to 100 and inheriting a hyperactive version of an enzyme that rebuilds telomeres - the tip ends ...
Nov 11, 2009 |
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