Adverse effect
hideIn medicine, an adverse effect is a harmful and undesired effect resulting from a medication or other intervention such as surgery. An adverse effect may be termed a "side effect", when judged to be secondary to a main or therapeutic effect, and may result from an unsuitable or incorrect dosage or procedure, which could be due to medical error. Adverse effects are sometimes referred to as "iatrogenic" because they are generated by a physician/treatment. Some adverse effects only occur only when starting, increasing or discontinuing a treatment. Using a drug or other medical intervention which is contraindicated may increase the risk of adverse effects. Adverse effects may cause medical complications of a disease or procedure and negatively affect its prognosis. They may also lead to non-compliance with a treatment regimen.
The harmful outcome is usually indicated by some result such as morbidity, mortality, alteration in body weight, levels of enzymes, loss of function, or as a pathological change detected at the microscopic, macroscopic or physiological level. It may also be indicated by symptoms reported by a patient. Adverse effects may cause a reversible or irreversible change, including an increase or decrease in the susceptibility of the individual to other chemicals, foods, or procedures, such as drug interactions.
In clinical trials, a distinction is made between adverse events (AEs) and serious adverse events (SAEs). Generally, any event which causes death, permanent damage, birth defects, or requires hospitalization is considered an SAE. The results of these trials are often included in the labeling of the medication to provide information both for patients and the prescribing physicians.
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News tagged with side effects
GAO: FDA yet to make safety changes post-Vioxx
Medicine & Health / Medications
Dec 09, 2009 |
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(AP) -- The Food and Drug Administration still hasn't restructured its staff to better monitor drug safety, more than three years after experts recommended key changes in the wake of the Vioxx scandal.
Second-line CML drugs evoke faster response than front-line therapy
Dec 07, 2009 |
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Two medications approved as treatment for drug-resistant chronic myeloid leukemia continue to provide patients with quicker, better responses as a first treatment than the existing front-line drug, researchers at The University ...
Drug shows positive responses, low side-effects in multiple myeloma
Dec 07, 2009 |
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NEW ORLEANS ― The second-generation proteasome inhibitor carfilzomib is showing noteworthy response rates and low levels of adverse side effects among multiple myeloma patients in a phase II clinical trial, researchers ...
Study confirms that cannabis is beneficial for multiple sclerosis
Medicine & Health / Neuroscience
Dec 04, 2009 |
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Cannabis can reduce spasticity in multiple sclerosis (MS) patients. A systematic review, published in the open access journal BMC Neurology, found that five out six randomized controlled trials reported a reduction in spa ...
Long-term testicular cancer survivors at high risk for neurological side effects
Nov 25, 2009 |
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Long-term survivors of testicular cancer who were treated with cisplatin-based chemotherapy had more severe side effects, including neurological side effects and Raynaud-like phenomena, than men who were not treated with ...
Research Finds Ritalin's Benefits in Treating Children with Autism
Nov 19, 2009 |
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(PhysOrg.com) -- UA researchers present evidence that the Ritalin is effective in treating preschoolers with Autism in a first-ever clinical trial to test the medication's efficacy with children with the disorder.
First use of antibody and stem cell transplantation to successfully treat advanced leukemia
Nov 05, 2009 |
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For the first time, researchers at Fred Hutchinson Cancer Research Center have reported the use of a radiolabeled antibody to deliver targeted doses of radiation, followed by a stem cell transplant, to successfully treat ...
Study points to new uses, unexpected side effects of already existing drugs
Nov 04, 2009 |
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Scientists at the University of North Carolina at Chapel Hill School of Medicine and the University of California, San Francisco have developed and experimentally tested a technique to predict new target diseases ...
Side effects not always due to swine flu shot
Oct 31, 2009 |
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(AP) -- Hundreds of people on any given day will die, develop the paralyzing Guillain-Barre syndrome or have spontaneous abortions, and that doesn't necessarily mean that their swine flu vaccination shot was to blame, a ...
The Medical Minute: Talk about prescriptions
Medicine & Health / Medications
Oct 28, 2009 |
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Look in your wallet, purse, personal digital assistant or smart phone and you probably have a list of names, phone numbers and addresses. You might even have a file for your passwords or important account numbers, birthdays ...
Study: HPV vaccine hurts less than expected
Medicine & Health / Medications
Oct 21, 2009 |
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(PhysOrg.com) -- Injections of the human papillomavirus (HPV) vaccine appear to be no more painful than other shots that prevent disease, according to a new study by researchers at the University of North Carolina at Chapel ...
Discovery of enzyme structure points way to creating less toxic anti-HIV drugs
Oct 15, 2009 |
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By discovering the atomic structure of a key human enzyme, researchers at The University of Texas at Austin have pointed the way toward designing anti-HIV drugs with far less toxic side effects.
Stanford analyses of flu pandemics project savings from earlier vaccinations
Oct 05, 2009 |
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In a city the size of New York, starting a vaccination campaign a few weeks earlier could save almost 600 lives and over $150 million, according to a study by scientists at the Stanford University School of Medicine.
Adverse drug events: a large burden in pediatric care
Sep 28, 2009 |
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(PhysOrg.com) -- An 11year national analysis at Children's Hospital Boston shows that side effects or accidental overdoses of medications are a common complication of outpatient care in children, generating more than half ...
Researchers find few side effects from radiation treatment given after prostate cancer surgery
Sep 28, 2009 |
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The largest single-institution study of its kind has found few complications in prostate cancer patients treated with radiotherapy after surgery to remove the prostate. Men in this study received radiotherapy after a prostate-specific ...
