The Janus kinase 2 (JAK2) protein mediates signaling from several cytokine receptors in the regulation of hematopoiesis and immune responses. Somatic mutations in human JAK2 lead to constitutive activation and cytokine-independent ...
Molecular & Computational biology
Apr 4, 2024
0
16
The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease. However, the CRISPR/Cas9 method can also result in unintended ...
Biotechnology
Sep 15, 2023
0
58
Single-cell RNA sequencing data are useful for studying cell phenotypes and function. However, deciphering the clonal relationships of cells is critical to understanding the patterns of cell migration during development and ...
Biotechnology
Aug 10, 2023
0
14
A study of the relationship between the growth rate of tropical trees and the frequency of genetic mutations they accumulate suggests that older, long-lived trees play a greater role in generating and maintaining genetic ...
Evolution
Jun 6, 2023
0
78
Induced pluripotent stem cells offer great therapeutic potential and are a valuable tool for understanding how different diseases develop. New research shows that such stem cell lines should be regularly screened for genetic ...
Cell & Microbiology
Mar 24, 2023
0
30
Scientists from Denmark and China have estimated germline mutation rates across vertebrates by sequencing and comparing genetic samples from 151 mother, father, and offspring trios from 68 species of mammals, fishes, birds ...
The male reproductive system serves as a hotspot for the emergence of new genes. Perhaps that explains why more new mutations are inherited from fathers than from mothers. It doesn't, however, clarify why older fathers pass ...
Evolution
Jan 12, 2023
0
46
In 1793, Capt. William Bligh docked the HMS Providence in Kingstown in St. Vincent and the Grenadines, a small island nation in the Caribbean Sea, with cargo filled with several hundred sapling breadfruit trees. His goal ...
Plants & Animals
Jan 5, 2023
3
649
In a discovery that challenges over a century of evolutionary conventional wisdom, corals have been shown to pass somatic mutations—changes to the DNA sequence that occur in non-reproductive cells—to their offspring. ...
Evolution
Aug 31, 2022
0
302
Astronauts are at higher risk for developing mutations—possibly linked to spaceflight—that can increase the risk of developing cancer and heart disease during their lifetimes, according to a first-of-its kind study from ...
Space Exploration
Aug 31, 2022
0
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