News tagged with splicing factors
Scientists trace extensive networks regulating alternative RNA splicing
Biology /
Sep 20, 2008 |
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[B]RNA targets of tissue-specific splicing factors Fox-1 and Fox-2 are successfully predicted[/B] Two professors at Cold Spring Harbor Laboratory (CSHL) have succeeded in tracing intricate biochemical networks involving a c ...
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Getting more from whole-transcript microarrays
May 21, 2009 |
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The widely-used Affymetrix Whole-Transcript Gene 1.0 ST (sense target) microarray platform, normally used to assay gene expression, can also be utilized to interrogate exon-specific splicing. Research published today in the ...
Alternative splicing proteins prompt heart development
Dec 08, 2008 |
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Just as the emotions it represents are dynamic, the heart's development requires dynamic shifts in proteins that prompt alternative spicing, a mechanism that allows a given gene to program the cell to make several proteins, ...
Researchers identify drug candidate for treating spinal muscular atrophy
Nov 04, 2009 |
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A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants. This is the finding of ...
Master Molecular Switch May Prevent the Spread of Cancer Cells to Distant Sites in the Body
Mar 16, 2009 |
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Researchers at the University of Pennsylvania School of Medicine have identified a master switch that might prevent cancer cells from metastasizing from a primary tumor to other organs. The switch is a protein ...
UVA reports surprising findings related to myotonic muscular dystrophy
Dec 17, 2007 |
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New research from the University of Virginia Health System shows that, in cases of Type 1 myotonic muscular dystrophy (DM1), a well known heart protein does several surprising things. DM1 is the most common form of muscular ...
Gene variation may be why some don't respond to cholesterol-lowering drugs
Jun 16, 2008 |
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A variation in the way the body processes a single protein may explain why some people don't respond well to drugs that lower "bad" cholesterol, according to a report in Circulation: Journal of the American Heart Association.
Possible help in fight against muscle-wasting disease (w/ Video)
Nov 06, 2009 |
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(PhysOrg.com) -- A compound already used to treat pneumonia could become a new therapy for an inherited muscular wasting disease, according to researchers at the University of Oregon and the University of ...
Living view in animals shows how cells decide to make proteins
Nov 30, 2006 |
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Scientists at Duke University Medical Center have visualized in a living animal how cells use a critical biological process to dice and splice genetic material to create unique and varied proteins.
Single letter in the human genome points to risk for high cholesterol
Dec 16, 2008 |
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(PhysOrg.com) -- Write out every letter in the human genome, one A, C, T or G per millimeter, and the text would be 1,800 miles long, roughly the distance from New York to Colorado. Now, in the search for genes that affect ...
Untangling a pathology of Alzheimer's
Sep 06, 2006 |
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Researchers have uncovered what appears to be a natural protective mechanism against a central cause of neuronal death in Alzheimer's and similar neurodegenerative diseases. They theorize that it may be possible to use drugs ...
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