News tagged with splicing
Researchers find mutation causing neurodegeneration
A Jackson Laboratory research team led by Professor and Howard Hughes Medical Investigator Susan Ackerman, Ph.D., has discovered a defect in the RNA splicing process in neurons that may contribute to neurological disease.
Jan 19, 2012 |
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Massive DNA search uncovers new mutations driving blood cancer
The most comprehensive search to date of DNA abnormalities in chronic lymphocytic leukemia (CLL) has unearthed several new altered genes that drive this common blood cancer, a finding that could potentially ...
Dec 12, 2011 |
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Genetic screening in yeast reveals new candidate gene for Lou Gehrig's disease
(Medical Xpress) -- Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a universally fatal neurodegenerative disease. Mutations in two related proteins, TDP-43 and FUS, cause some forms of ALS. ...
Nov 15, 2011 |
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Study reveals details of alternative splicing circuitry that promotes cancer's Warburg effect
Cancer cells maintain their life-style of extremely rapid growth and proliferation thanks to an enzyme called PK-M2 (pyruvate kinase M2) that alters the cells' ability to metabolize glucose – a phenomenon known as the ...
Nov 02, 2011 |
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Temperature controls the genetic message
Alternative splicing, the mechanism enabling a gen to encode different proteins, according to the cell's needs, still holds many secrets. It has transformed the initial theory of one gen, one protein, but how it is controlled ...
Sep 16, 2011 |
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Researchers discover a switch that controls stem cell pluripotency
Scientists have found a control switch that regulates stem cell "pluripotency," the capacity of stem cells to develop into any type of cell in the human body. The discovery reveals that pluripotency is regulated by a single ...
Sep 15, 2011 |
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New link found between obesity and insulin resistance
Obesity is the main culprit in the worldwide avalanche of type 2 diabetes. But how excess weight drives insulin resistance, the condition that may lead to the disease, is only partly understood. Scientists at Joslin Diabetes ...
Aug 02, 2011 |
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New mechanism in the regulation of human genes
Scientists at the Technical University of Munich and the Helmholtz Zentrum Muenchen and along with their colleagues from the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Centre for Genomic Regulation ...
Jul 14, 2011 |
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New information revealed about a protein implicated in autism and similar disorders; could lead to better drug design
(Medical Xpress) -- University of Michigan researcher Gabrielle Rudenko and her Life Sciences Institute lab have solved the structure of a protein that is implicated in a number of neuropsychiatric disorders including autism ...
Jul 08, 2011 |
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Many hereditary conditions associated with errors in pre-mRNA splicing, study suggests
A new Brown University computer analysis that predicts the effect of genetic mutations on how the body splices mRNA indicates as many as a third of disease-related mutations may be linked to splicing problems -- more than ...
Jun 13, 2011 |
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Genetic mutation linked to lethal disease
Researchers have identified a genetic mutation found in the Ohio Amish population as the cause of a fatal developmental disease in fetuses and infants, according to research published in the April 8, 2011, issue of Science.
Apr 18, 2011 |
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Lasers, custom microscope show gene splicing process in real time
From neurosurgery to bar code readers, lasers have been used in a myriad of applications since they were first introduced in the late 1950's. Now, with the work being done in Jeff Gelles' Lab at Brandeis University, ...
Mar 10, 2011 |
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Engineered molecule changes itself to detect and attack diseased cells
(PhysOrg.com) -- Assistant Professor of Bioengineering Christina Smolke has engineered biological molecules that regulate a cell's behavior by adjusting their own forms and functions in response to the internal conditions ...
Nov 30, 2010 |
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Cancer-associated long non-coding RNA regulates pre-mRNA splicing
Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production. Their study appears in the ...
Sep 23, 2010 |
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Researchers crack 'splicing code,' solve a mystery underlying biological complexity
Researchers at the University of Toronto have discovered a fundamentally new view of how living cells use a limited number of genes to generate enormously complex organs such as the brain.
May 05, 2010 |
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