Statin
hideThe statins (or HMG-CoA reductase inhibitors) are a class of drugs that lower cholesterol levels in people with or at risk of cardiovascular disease.
They lower cholesterol by inhibiting the enzyme HMG-CoA reductase, which is the rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis. Inhibition of this enzyme in the liver results in decreased cholesterol synthesis as well as increased synthesis of LDL receptors, resulting in an increased clearance of low-density lipoprotein (LDL) from the bloodstream. The first results can be seen after one week of use and the effect is maximal after four to six weeks.
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News tagged with statins
Muscle damage may be present in some patients taking statins
Jul 06, 2009 |
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Structural muscle damage may be present in patients who have statin-associated muscle complaints, found a new study in CMAJ (Canadian Medical Association Journal) .
Statins can protect against Alzheimer's disease
Jun 22, 2009 |
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High cholesterol levels are considered to be a risk factor not only for cardiovascular disease including stroke, but also for the development of Alzheimer's disease. Therefore, many cholesterol lowering drugs, including statins, ...
Cholesterol-lowering drugs may help prevent stroke recurrence
Medicine & Health / Neuroscience
May 25, 2009 |
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People who take cholesterol-lowering drugs called statins after a stroke may be less likely to have another stroke later, according to research published in the May 26, 2009, print issue of Neurology.
Statins alter prostate cancer patients' PSA levels
Apr 28, 2009 |
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Beyond lowering cholesterol, statin medications have been found to have numerous other health benefits, including lowering a healthy man's risk of developing advanced prostate cancer, as well as lowering his prostate-specific ...
Get personal to improve heart health
Feb 23, 2009 |
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Scare tactics may not be necessary when trying to get patients at risk of heart disease to change their diet or behaviour, a new study has found. Instead, doctors and nurses should be aware of the stage of life their patients ...
First comprehensive paper on statins' adverse effects released
Medicine & Health / Medications
Jan 27, 2009 |
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A paper co-authored by Beatrice Golomb, MD, PhD, associate professor of medicine at the University of California, San Diego School of Medicine and director of UC San Diego's Statin Study group cites nearly 900 studies on ...
