Hematopoietic stem cell transplantation
hideHematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (in this case known as bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of hematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer.
With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoietic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting peripheral blood stem cells provides a bigger graft, does not require that the donor be subjected to general anesthesia to collect the graft, results in a shorter time to engraftment, and may provide for a lower long-term relapse rate.
Hematopoietic stem cell transplantation remains a risky procedure with many possible complications; it has traditionally been reserved for patients with life-threatening diseases. While occasionally used experimentally in nonmalignant and nonhematologic indications such as severe disabling auto-immune disease and cardiovascular disease, the risk of fatal complications appears too high to gain wider acceptance.
For more information about Hematopoietic stem cell transplantation, read the full article at
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News tagged with stem cell transplantation
'Mini' transplant may reverse severe sickle cell disease
Dec 09, 2009 |
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Results of a preliminary study by scientists at the National Institutes of Health and Johns Hopkins show that "mini" stem cell transplantation may safely reverse severe sickle cell disease in adults.
Autologous stem cell transplantation for soft tissue sarcoma: insufficient research into therapy
Dec 08, 2009 |
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Due to a lack of suitable studies, it is unclear whether patients with soft tissue sarcoma can benefit from autologous haematopoietic stem cell transplantation. With this type of therapy, some of the patient's own (autologous) ...
Gene mismatch influences success of bone marrow transplants
Nov 22, 2009 |
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A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of Nature Ge ...
Researchers find two units of umbilical cord blood reduce risk of leukemia recurrence
Nov 13, 2009 |
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A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease ...
Rare genetic disease successfully reversed using stem cell transplantation
Sep 17, 2009 |
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A recent study by Scripps Research Institute scientists offers good news for families of children afflicted with the rare genetic disorder, cystinosis. In research that holds out hope for one day developing a potential therapy ...
Researchers learn how blood cells 'talk'
Aug 05, 2009 |
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(PhysOrg.com) -- Researchers at the University of Toronto have developed a new model that explains how cells communicate and specifically reveals how blood cells "talk" to each other. The result could help transform treatments ...
Donor stem cell transplantation associated with survival benefit for patients with leukemia
Jun 10, 2009 |
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An analysis of previous studies indicates that allogeneic stem cell transplantation (SCT) (stem cells from a compatible donor) is associated with significant overall and relapse-free survival benefit among adult patients ...
New therapy enlists immune system to boost cure rate in a childhood cancer
May 27, 2009 |
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A multicenter research team has announced encouraging results for an experimental therapy using elements of the body's immune system to improve cure rates for children with neuroblastoma, a challenging cancer of the nervous ...
The egg makes sure that sperm don't get too old
Mar 25, 2009 |
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In contrast to women, men are fertile throughout life, but research at the Sahlgrenska Academy, University of Gothenburg, Sweden, has now shown that a fertilising sperm can get help from the egg to rejuvenate. The result ...
Stem cell infusion and hyperbaric oxygen treatment improve islet function in diabetes
Mar 12, 2009 |
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A study to determine if patients with type 2 diabetes can benefit from a combination of autologous (patient self-donated) stem cell infusions (ASC) and hyperbaric (above the normal air pressure of ) oxygen treatment (HBO) ...
Multiple route bone marrow stem cell injections show promise to treat spinal cord injury
Mar 12, 2009 |
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Researchers from DaVinci Biosciences, Costa Mesa, California, in collaboration with Hospital Luis Vernaza in Ecuador, have determined that injecting a patient's own bone marrow-derived stem cells (autologous BMCs) directly ...
