Shining light on the radical production of DNA building blocks

Despite its fundamental role in biology and extensive studies over half a century, many aspects of how DNA's building blocks are formed remain unclear. Now, an international team of scientists has revealed valuable details ...

Neural network helps design brand new proteins

With their intricate arrangements and dynamic functionalities, proteins perform a plethora of biological tasks by employing unique arrangements of simple building blocks where geometry is key. Translating this nearly limitless ...

Why synonymous mutations are not always silent

New modeling shows how synonymous mutations—those that change the DNA sequence of a gene but not the sequence of the encoded protein—can still impact protein production and function. A team of researchers led by Penn ...

Tiny sea creature's genes shed light on evolution of immunity

How a tiny marine invertebrate distinguishes its own cells from competitors' bears striking similarities to the human immune system, according to a new study led by University of Pittsburgh School of Medicine researchers.

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