Related topics: breast cancer , women
Tamoxifen
hideTamoxifen is an antagonist of the estrogen receptor in breast tissue and is therefore used in the treatment of breast cancer. As of 2004, it was the world's largest selling drug for that purpose.
Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.
Tamoxifen was discovered by ICI Pharmaceuticals (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."
For more information about Tamoxifen, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
News tagged with tamoxifen
High-risk women reluctant to take tamoxifen to prevent breast cancer, study finds
Dec 03, 2009 |
1 / 5 (1) |
1
Even when women at high-risk of breast cancer are well-informed about the risks and benefits of using the drug tamoxifen for prevention, only 6 percent said they were likely to take it.
Estrogen receptor-alpha, breast cancer patients and tamoxifen response
Nov 25, 2009 |
not rated yet |
0
Researchers have found evidence of a statistically significant survival benefit from adjuvant tamoxifen among patients whose estrogen receptor (ER)-positive tumors had high levels of phosphorylation of ER-alpha; at serine-118 ...
Landmark study confirms chemotherapy benefit in breast cancer patients
Dec 11, 2009 |
not rated yet |
0
Chemotherapy generally improves survival in postmenopausal breast cancer patients, according to a landmark study led by Dr. Kathy Albain of Loyola University Health System.
Most Oncologists Feel New Genetic Test for Tamoxifen Sensitivity Not Ready for the Clinic
Dec 11, 2009 |
not rated yet |
0
(PhysOrg.com) -- Despite commercial availability and direct to consumer marketing of a new genetic test designed to reveal a breast cancer patient’s sensitivity to tamoxifen, most physicians in the U.S. are not currently ...
Search results for tamoxifen
Chicago Cancer Genome Project studies genetics of 1,000 tumors
Dec 22, 2009 |
5 / 5 (2) |
0
No two tumors are alike, but analyzing the genetics of cancers from different parts of the body may reveal surprising details useful for treatment and prevention.
Anti-estrogens may offer protection against lung cancer mortality
Dec 11, 2009 |
not rated yet |
0
Anti-estrogens as therapy for breast cancer may also reduce the risk of death from lung cancer, according to study results presented at the CTRC-AACR San Antonio Breast Cancer Symposium, held here Dec. 9-13, 2009.
Women with breast cancer who consume soy food have lower risk of cancer recurrence
Dec 08, 2009 |
not rated yet |
0
Although there is a concern regarding the safety of soy food consumption among breast cancer survivors, researchers have found that women in China who had breast cancer and a higher intake of soy food had an associated lower ...
Spices halt growth of breast stem cells, study finds
Dec 07, 2009 |
5 / 5 (2) |
0
A new study finds that compounds derived from the spices turmeric and pepper could help prevent breast cancer by limiting the growth of stem cells, the small number of cells that fuel a tumor's growth.
List of search results for tamoxifen
