News tagged with topoisomerase
Secrets revealed about how disease-causing DNA mutations occur
A team of Penn State scientists has shed light on the processes that lead to certain human DNA mutations that are implicated in hundreds of inherited diseases such as tuberous sclerosis and neurofibromatosis ...
Jul 02, 2009 |
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Gene alterations associated with response to anthracycline therapy for breast cancer
Alterations in the topoisomerase II alpha (TOP2A) gene were associated with better patient outcomes following anthracycline-based therapy compared with non-anthracycline-based regimens, according to a study in the April ...
Apr 28, 2009 |
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Ganetespib showed activity in KRAS-mutant NSCLC as monotherapy and in combinations
The investigational drug ganetespib, a synthetic second-generation Hsp90 inhibitor, slowed the growth of cancer cells taken from non-small cell lung cancer tumors with a mutation in the KRAS gene. The drug was even more active ...
Jan 11, 2012 |
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New discovery could lead to treatment for Angelman syndrome
Results of a new study from the University of North Carolina at Chapel Hill may help pave the way to a treatment for a neurogenetic disorder often misdiagnosed as cerebral palsy or autism.
Dec 21, 2011 |
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Research into chromosome replication reveals details of heredity dynamics
(PhysOrg.com) -- A novel study from Karolinska Institutet has deepened the understanding of how chromosome replication, one of life's most fundamental processes, works. In a long term perspective these results could eventually ...
Mar 03, 2011 |
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Image of new antibiotic in action opens up new opportunities to combat antibacterial resistance
Detailed pictures published today reveal how a new type of experimental antibiotic can kill bacteria that are already resistant to existing treatments. The findings could ultimately help scientists to develop new antibiotics ...
Aug 04, 2010 |
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Preventing cells from getting the kinks out of DNA
(PhysOrg.com) -- Many standard antibiotics and anti-cancer drugs block the enzymes that snip the kinks and knots out of DNA -DNA tangles are lethal to cells - but the drugs are increasingly encountering resistant bacteria ...
May 21, 2010 |
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Soy peptide lunasin has anti-cancer, anti-inflammatory properties
Two new University of Illinois studies report that lunasin, a soy peptide often discarded in the waste streams of soy-processing plants, may have important health benefits that include fighting leukemia and blocking the inflammation ...
Dec 02, 2009 |
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DNA with a twist: New company to search for cancer drugs and antibiotics
A new company has joined the fight against MRSA and cancer. Researchers at the John Innes Centre (Norwich) have launched a new company, Inspiralis Ltd, based around their expertise in DNA topoisomerases – ...
Feb 13, 2008 |
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First look at an enzyme target for antibacterial and cancer drugs
The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and replication, and is a prime target of antibacterial and anticancer drugs. Researchers with the U.S. Department ...
Biology /
Dec 20, 2007 |
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Direct evidence that bioclocks control chromosome coiling
There is a new twist on the question of how biological clocks work. In recent years, scientists have discovered that biological clocks help organize a dizzying array of biochemical processes in the body. Despite ...
Biology /
Nov 21, 2007 |
4.6 / 5 (11) |
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Nanotweezers Unlock Anticancer Drug Secrets
The annoying bulges of an overwound telephone cord that shorten its reach and limit a caller’s motion help explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators led by ...
Nanotechnology / Bio & Medicine
Aug 22, 2007 |
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List of search results for topoisomerase
