Tumor suppressor gene
hideA tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.
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News tagged with tumor suppressor gene
Loss of tumor supressor gene essential to transforming benign nerve tumors into cancers
Oct 13, 2009 |
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Researchers at UCLA's Jonsson Comprehensive Cancer Center showed for the first time that the loss or decreased expression of the tumor suppressor gene PTEN plays a central role in the malignant transformation of benign nerve ...
New type of adult stem cells found in the prostate may be involved in prostate cancer development
Sep 09, 2009 |
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A new type of stem cell discovered in the prostate of adult mice can be a source of prostate cancer, according to a new study by researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical ...
Researchers discover new targets for treatment of invasive breast cancer
Aug 19, 2009 |
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Research led by Suresh Alahari, PhD, Associate Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, has shown for the first time that a tiny piece of RNA appears to play a major role ...
Mathematical modeling predicts response to Herceptin
Jul 28, 2009 |
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Cancer researchers are turning to mathematical models to help answer important clinical questions, and a new paper in Cancer Research, a journal of the American Association for Cancer Research, illustrates how the techni ...
Toward new drugs that turn genes on and off
Jun 04, 2009 |
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Scientists in Michigan and California are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, ...
A surprise 'spark' for pre-cancerous colon polyps
May 14, 2009 |
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Researchers at Huntsman Cancer Institute (HCI) at the University of Utah studied the events leading to colon cancer and found that an unexpected protein serves as the "spark" that triggers formation of colon polyps, the precursors ...
Fat droplet nanoparticle delivers tumor suppressor gene to tumor and metastatic cells
Nanotechnology / Bio & Medicine
Apr 20, 2009 |
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Dr. Esther Chang describes the most recent developments in human trials of the first systemic, non-viral, tumor-targeted, nanoparticle method designed to restore normal gene function to tumor cells while completely bypassing ...
Chemopreventive isothiocyanates selectively depletes mutant p53 in tumor cells
Apr 20, 2009 |
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Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have demonstrated that naturally-occurring compounds can selectively deplete mutant p53 and restore "wild type" function to p53 in ...
Gene helps protect tumor suppressor in breast cancer
Apr 06, 2009 |
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Scientists at The University of Texas M. D. Anderson Cancer Center have discovered a gene that protects PTEN, a major tumor-suppressor that is reduced but rarely mutated in about half of all breast cancers.
New melanoma tumor suppressor gene uncovered
Mar 29, 2009 |
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National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a s ...
