News tagged with tumor suppressor p53
Tumor suppressor pulls double shift as reprogramming watchdog
Aug 09, 2009 |
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A collaborative study by researchers at the Salk Institute for Biological Studies uncovered that the tumor suppressor p53, which made its name as "guardian of the genome", not only stops cells that could become ...
The 2 faces of Mdmx: Why some tumors don't respond to radiation and chemotherapy
Jul 06, 2009 |
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A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells. In their latest study, ...
Potent metastasis inhibitor identified
Jun 22, 2009 |
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Researchers at Children's Hospital Boston have isolated a potent inhibitor of tumor metastasis made by tumor cells, one that could potentially be harnessed as a cancer treatment. Their findings were published in the online ...
SIRT1 takes down tumors
Apr 13, 2009 |
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Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division. The study will be published online ...
Search results for tumor suppressor p53
Chemopreventive isothiocyanates selectively depletes mutant p53 in tumor cells
Apr 20, 2009 |
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Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have demonstrated that naturally-occurring compounds can selectively deplete mutant p53 and restore "wild type" function to p53 in ...
Effect of mutant p53 stability on tumorigenesis and drug design
May 15, 2008 |
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In the May 15th issue of G&D, Dr. Guillermina Lozano (MD Anderson Cancer Center) and colleagues reveal how the stabilization of a mutated form of p53 affects oncogenesis, and lends startling new insight into the potential ...
Researchers pinpoint a new enemy for tumor-suppressor p53
Jun 26, 2009 |
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Researchers at The University of Texas M. D. Anderson Cancer Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer ...
Fat droplet nanoparticle delivers tumor suppressor gene to tumor and metastatic cells
Nanotechnology / Bio & Medicine
Apr 20, 2009 |
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Dr. Esther Chang describes the most recent developments in human trials of the first systemic, non-viral, tumor-targeted, nanoparticle method designed to restore normal gene function to tumor cells while completely bypassing ...
Stabilizing cancer-fighting p53 can also shield a metastasis-promoter
May 22, 2008 |
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Efforts to protect the tumor-suppressor p53 could just as easily shelter a mutant version of the protein, causing cancer cells to thrive and spread rather than die, according to research by scientists at The University of ...
Research shows cell's inactive state is critical for effectiveness of cancer treatment
Biology /
Jan 09, 2009 |
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A new study sheds light on a little understood biological process called quiescence, which enables blood-forming stem cells to exist in a dormant or inactive state in which they are not growing or dividing. According to the ...
MicroRNA undermines tumor suppression
Mar 17, 2009 |
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A small piece of RNA, or microRNA (miRNA), ratchets down the activity of the tumor-suppressor gene p53, according to a study by Whitehead Institute and National University of Singapore researchers.
How eating fruit and vegetables can improve cancer patients' response to chemotherapy
Oct 22, 2008 |
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The leading cause of death in all cancer patients continues to be the resistance of tumor cells to chemotherapy, a form of treatment in which chemicals are used to kill cells.
Antitumor activity of nutlin-3 in neuroblastoma with wild-type p53
Nov 10, 2009 |
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The small-molecule inhibitor nutlin-3 may be a viable treatment option for neuroblastoma patients with wild-type p53 activity, according to a new study published online November 10 in the Journal of the National Cancer In ...
Researchers discover how tumor suppressor inhibits cell growth
Aug 07, 2008 |
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Genes that inhibit the spontaneous development of cancer are called tumor suppressor genes. One of the major tumor suppressors is p53, a protein that acts in the cell nucleus to control the expression of other genes whose ...
List of search results for tumor suppressor p53
