Tumor suppressor gene
hideA tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.
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News tagged with tumor suppressor
Novel 'On-Off Switch' Mechanism Stops Cancer in Its Tracks
Sep 11, 2009 |
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(PhysOrg.com) -- A tiny bit of genetic material with no previously known function may hold the key to stopping the spread of cancer, researchers at Yale School of Medicine and Sichuan University in Chengdu, ...
Escape cancer, but age sooner? The dark side of the tumor suppressing process
Biology /
Dec 02, 2008 |
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Cells shut down and stop dividing when their DNA is damaged, in a process known as cellular senescence, so as to prevent damaged DNA from leading to unregulated cell division and therefore cancer. However, a new study, published ...
Does sugar feed cancer?
Aug 17, 2009 |
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Researchers at Huntsman Cancer Institute at the University of Utah have uncovered new information on the notion that sugar "feeds" tumors. The findings may also have implications for other diseases such as diabetes. The research ...
Toward new drugs that turn genes on and off
Jun 04, 2009 |
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Scientists in Michigan and California are reporting an advance toward development of a new generation of drugs that treat disease by orchestrating how genes in the body produce proteins involved in arthritis, ...
SIRT1 takes down tumors
Apr 13, 2009 |
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Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division. The study will be published online ...
New melanoma tumor suppressor gene uncovered
Mar 29, 2009 |
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National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a s ...
Potent metastasis inhibitor identified
Jun 22, 2009 |
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Researchers at Children's Hospital Boston have isolated a potent inhibitor of tumor metastasis made by tumor cells, one that could potentially be harnessed as a cancer treatment. Their findings were published in the online ...
Team identifies 13 new tumor-suppressor genes in liver cancer
Nov 18, 2008 |
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Over the years, hunting for cancer-related genes and understanding how they work has been an important, although time-consuming, exercise. At Cold Spring Harbor Laboratory (CSHL), five different research groups have now combined ...
Fat droplet nanoparticle delivers tumor suppressor gene to tumor and metastatic cells
Nanotechnology / Bio & Medicine
Apr 20, 2009 |
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Dr. Esther Chang describes the most recent developments in human trials of the first systemic, non-viral, tumor-targeted, nanoparticle method designed to restore normal gene function to tumor cells while completely bypassing ...
Carbohydrate acts as tumor suppressor
Jul 06, 2009 |
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Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specialized complex sugar molecules (glycans) that anchor cells into place act as tumor suppressors in breast and prostate cancers. These ...
Tiny RNA has big impact on lung cancer tumors
Dec 07, 2009 |
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Researchers from Yale University and Mirna Therapeutics, Inc., reversed the growth of lung tumors in mice using a naturally occurring tumor suppressor microRNA. The study reveals that a tiny bit of RNA may one day play a ...
Researchers find gene function 'lost' in melanoma and glioblastoma
Dec 15, 2008 |
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Researchers at Georgetown University Medical Center have found a gene they say is inactivated in two aggressive cancers – malignant melanoma, a form of skin cancer, and glioblastoma multiforme, a lethal brain tumor. They ...
New insights into the regulation of PTEN tumor suppression function
Aug 20, 2008 |
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The PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration of the gene is so common among various ...
New location found for regulation of RNA fate
Jul 30, 2009 |
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Thousands of scientists and hundreds of software programmers studying the process by which RNA inside cells normally degrades may soon broaden their focus significantly.
Tumor suppressor pulls double shift as reprogramming watchdog
Aug 09, 2009 |
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A collaborative study by researchers at the Salk Institute for Biological Studies uncovered that the tumor suppressor p53, which made its name as "guardian of the genome", not only stops cells that could become ...
